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657021 Tyrosine Kinase Inhibitor Set II - Calbiochem

The Tyrosine Kinase Inhibitor Set II controls the biological activity of Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: EGFR
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Overview

Replacement Information
Description
OverviewContains 20 mg of Genistein (Cat. No. 345834), 1 mg of PP2 (Cat. No. 529573), 5 mg of AG 490 (Cat. No. 658401), 5 mg of AG 1296 (Cat. No. 658551), and 5 mg of AG 1478 (Cat. No. 658552). Supplied with an informational insert.
Catalogue Number657021
Brand Family Calbiochem®
Application Data
References
ReferencesHanke, J.H., et al. 1996. J. Biol. Chem. 271 695.
Meydan, N., et al. 1996. Nature 379, 645.
Levitzi, A., and Gazit, A. 1995. Science 267, 1782.
Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592.
Product Information
ATP CompetitiveY
FormSolid
Quality LevelMQ100
Applications
Biological Information
Primary TargetEGFR
Secondary targetPKC, Src family of protein tyrosine kinases, JAK2
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
657021 0

Documentation

Tyrosine Kinase Inhibitor Set II - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Tyrosine Kinase Inhibitor Set II - Calbiochem Certificates of Analysis

TitleLot Number
657021

References

Reference overview
Hanke, J.H., et al. 1996. J. Biol. Chem. 271 695.
Meydan, N., et al. 1996. Nature 379, 645.
Levitzi, A., and Gazit, A. 1995. Science 267, 1782.
Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592.

Brochure

Title
Protein Kinase Assay and Detection Kits Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-September-2008 RFH
Application Data
DescriptionProtein tyrosine phosphorylation is a key element in several membrane signal transduction systems. There are two general classes of tyrosine kinases: the receptor tyrosine kinases and the receptor-associated tyrosine kinases. The receptor tyrosine kinases possess an extracellular ligand binding domain and an intracellular catalytic domain with intrinsic tyrosine kinase activity. The receptor-associated tyrosine kinases transmit signals from the membrane by interacting with the cytoplasmic domain of membrane proteins.

The design of specific inhibitors of tyrosine kinases is important for both fundamental research and for developing therapeutic strategies for the treatment of cancer, atherosclerosis, psoriasis, septic shock, and other disorders where increased tyrosine kinase activity has been reported.

The Tyrosine Kinase Inhibitor Set contains a general tyrosine kinase inhibitor and a series of other inhibitors, which are selective for various tyrosine kinases that are important in cellular signaling. The set contents and characteristics are listed in the table below.
FormSolid
Intert gas (Yes/No) Packaged under inert gas
SolubilityConcentrated solutions of ≥1 mg/ml should be prepared in anhydrous DMSO.
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesHanke, J.H., et al. 1996. J. Biol. Chem. 271 695.
Meydan, N., et al. 1996. Nature 379, 645.
Levitzi, A., and Gazit, A. 1995. Science 267, 1782.
Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592.