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616430 TGF-α, Human, Recombinant, E. coli

TGF-α, Human, Recombinant, E. coli MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Transforming Growth Factor-α

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Overview

Replacement Information

Key Spec Table

Purity
≥97% by SDS-PAGE
Description
Overview

This product has been discontinued.



Recombinant, human transforming growth factor-α expressed in E. coli. Plays an important role in cell-cell adhesion and cell growth and differentiation. Reported to play a role in the development of hormonal insensitivity in estrogen-receptor-positive breast cancers.
Catalogue Number616430
Brand Family Calbiochem®
SynonymsTransforming Growth Factor-α
References
ReferencesNicholson, R.I., et al. 1994. Cancer Res. 54, 1684.
Anklesaria, P., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 3289.
Massague, J. 1990. J. Biol. Chem. 265, 21393.
Watanabe, S., et al. 1987. Proc. Natl. Acad. Sci. USA 84, 1258.
Schreiber, A.B., et al. 1986. Science 232, 1250.
Tam, J.P. 1985. Science 229, 673.
Derynck, R., et al. 1984. Cell 38, 327.
Product Information
CAS number105186-99-0
FormLyophilized
FormulationLyophilized from 30% acetonitrile, 0.1% TFA.
Quality LevelMQ100
Applications
Biological Information
Biological activityED₅₀= 0.1-0.4 ng/ml as measured by the ability to stimulate ³H-thymidine incorporation in the mouse fibroblast cell line Balb/3T3
Purity≥97% by SDS-PAGE
Physicochemical Information
ContaminantsEndotoxin: ≤100 pg/µg TGF-α
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long-term storage or refrigerate (4°C) for short-term storage. Avoid freeze/thaw cycles of solutions. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -70°C.
Canadian export regulations Due to the country and/or U.S. state of origin of the animal material used in this product, this product may not be exported to Canada.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
616430 0

Documentation

TGF-α, Human, Recombinant, E. coli SDS

Title

Safety Data Sheet (SDS) 

TGF-α, Human, Recombinant, E. coli Certificates of Analysis

TitleLot Number
616430

References

Reference overview
Nicholson, R.I., et al. 1994. Cancer Res. 54, 1684.
Anklesaria, P., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 3289.
Massague, J. 1990. J. Biol. Chem. 265, 21393.
Watanabe, S., et al. 1987. Proc. Natl. Acad. Sci. USA 84, 1258.
Schreiber, A.B., et al. 1986. Science 232, 1250.
Tam, J.P. 1985. Science 229, 673.
Derynck, R., et al. 1984. Cell 38, 327.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-September-2008 RFH
SynonymsTransforming Growth Factor-α
DescriptionRecombinant, human transforming growth factor-α expressed in E. coli. Plays an important role in cell-cell adhesion and cell growth and differentiation. Reported to play a role in the development of hormonal insensitivity in estrogen-receptor-positive breast cancers.
FormLyophilized
FormulationLyophilized from 30% acetonitrile, 0.1% TFA.
CAS number105186-99-0
Purity≥97% by SDS-PAGE
ContaminantsEndotoxin: ≤100 pg/µg TGF-α
Biological activityED₅₀= 0.1-0.4 ng/ml as measured by the ability to stimulate ³H-thymidine incorporation in the mouse fibroblast cell line Balb/3T3
SolubilityReconstitute to a concentration of ≥10 µg/ml with sterile 10 mM acetic acid containing ≥0.1% HSA or BSA.
Storage ≤ -70°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long-term storage or refrigerate (4°C) for short-term storage. Avoid freeze/thaw cycles of solutions. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -70°C.
Toxicity Standard Handling
ReferencesNicholson, R.I., et al. 1994. Cancer Res. 54, 1684.
Anklesaria, P., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 3289.
Massague, J. 1990. J. Biol. Chem. 265, 21393.
Watanabe, S., et al. 1987. Proc. Natl. Acad. Sci. USA 84, 1258.
Schreiber, A.B., et al. 1986. Science 232, 1250.
Tam, J.P. 1985. Science 229, 673.
Derynck, R., et al. 1984. Cell 38, 327.