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616450 Sigma-AldrichTGF-β1, Human Platelets

TGF-β1, Human Platelets MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
CoA
References
Data Sheet

Synonyms: hTGF-β1, Transforming Growth Factor-β1

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Overview

Replacement Information

Key Spec Table

Purity
≥97% by SDS-PAGE

Description
Overview	Native transforming growth factor-β1 from human platelets. Promotes apoptosis in resting human B lymphocytes, glioma cells, and trigeminal neurinomal cells.
Catalogue Number	616450
Brand Family	Calbiochem®
Synonyms	hTGF-β1, Transforming Growth Factor-β1

References
References	Lomo, J., et al. 1995. J. Immunol. 154, 1634. Marushige, K. and Marushige, Y. 1995. Anticancer Res. 14, 2419. Bermundez, L.E. 1993. J. Immunol. 150, 1838. Hamilton, J.A., et al. 1993. J. Immunol. 150, 1496. Reilly, J.T., et al. 1993. Br. J. Haematol. 83, 58. Sporn, M.B. and Roberts, A.B. 1993. Growth Factors 8, 1.

Product Information
Form	Lyophilized
Formulation	Lyophilized from a sterile-filtered solution of 50 µg BSA/µg TGF-β1, 35% acetonitrile, 0.1% TFA.
Quality Level	MQ100

Applications

Biological Information
Biological activity	ED₅₀ = 40-10 pg/ml as measured by the inhibition of IL-4-dependant proliferation of mouse HT-2 cells using resazurin dye as an indicator of cell proliferation.
Purity	≥97% by SDS-PAGE
Source	Prepared from blood that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Physicochemical Information
Contaminants	Endotoxin: ≤1 EU/ug of TGF-β1

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, store in the refrigerator (4°C) for short-term storage or freeze (-20°C) for long-term storage. Avoid freeze/thaw cycles of solutions. Stock solutions are stable for up to 1 months at 4°C or up to 3 months at -20°C..

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
Catalogue Number	GTIN
616450	0

Documentation

TGF-β1, Human Platelets SDS

Title
Safety Data Sheet (SDS)

TGF-β1, Human Platelets Certificates of Analysis

Title	Lot Number
616450	Enter Lot Number

References

Reference overview
Lomo, J., et al. 1995. J. Immunol. 154, 1634. Marushige, K. and Marushige, Y. 1995. Anticancer Res. 14, 2419. Bermundez, L.E. 1993. J. Immunol. 150, 1838. Hamilton, J.A., et al. 1993. J. Immunol. 150, 1496. Reilly, J.T., et al. 1993. Br. J. Haematol. 83, 58. Sporn, M.B. and Roberts, A.B. 1993. Growth Factors 8, 1.

Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	19-May-2008 RFH
Synonyms	hTGF-β1, Transforming Growth Factor-β1
Description	Native transforming growth factor-β1 from human platelets. Promotes apoptosis in resting human B lymphocytes, glioma cells, and trigerminal neurinomal cells.
Form	Lyophilized
Formulation	Lyophilized from a sterile-filtered solution of 50 µg BSA/µg TGF-β1, 35% acetonitrile, 0.1% TFA.
Source	Prepared from blood that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Purity	≥97% by SDS-PAGE
Contaminants	Endotoxin: ≤1 EU/ug of TGF-β1
Biological activity	ED₅₀ = 40-10 pg/ml as measured by the inhibition of IL-4-dependant proliferation of mouse HT-2 cells using resazurin dye as an indicator of cell proliferation.
Solubility	Reconstitute to a concentration ≥10 µg/ml in sterile 4 mM HCl containing ≥0.1% HSA or BSA.
Storage	Avoid freeze/thaw -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, store in the refrigerator (4°C) for short-term storage or freeze (-20°C) for long-term storage. Avoid freeze/thaw cycles of solutions. Stock solutions are stable for up to 1 months at 4°C or up to 3 months at -20°C..
Toxicity	Standard Handling
Merck USA index	14, 9572
References	Lomo, J., et al. 1995. J. Immunol. 154, 1634. Marushige, K. and Marushige, Y. 1995. Anticancer Res. 14, 2419. Bermundez, L.E. 1993. J. Immunol. 150, 1838. Hamilton, J.A., et al. 1993. J. Immunol. 150, 1496. Reilly, J.T., et al. 1993. Br. J. Haematol. 83, 58. Sporn, M.B. and Roberts, A.B. 1993. Growth Factors 8, 1.

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