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575310 T0901317 - CAS 293754-55-9 - Calbiochem

A cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC₅₀ of 20 nM for LXRα).

T0901317 - CAS 293754-55-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: TO-901317, N-(2,2,2-Trifluoroethyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]sulfonamide

Primary Target: Liver X receptor (LXRα)
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
293754-55-9C₁₇H₁₂NSO₃F₉

Products

Catalogue NumberPackaging Qty/Pack
575310-10MG Plastic ampoule 10 mg
Description
OverviewA cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC50 of 20 nM for LXRα). Reported to induce the expression of genes associated with fatty acid biosynthesis and raise both the levels of serum HDL cholesterol and triglyceride in mice. Also reduces the development of atherosclerosis in LDL receptor-deficient mice and lowers plasma glucose in diabetic rodents.
Catalogue Number575310
Brand Family Calbiochem®
SynonymsTO-901317, N-(2,2,2-Trifluoroethyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]sulfonamide
References
ReferencesTerasaka, N., et al. 2003. FEBS Lett. 536, 6.
Cao, G., et al. 2002. J. Biol. Chem. 278, 1131.
Field, F.J., et al. 2002. Biochem. J. 368, 855.
Fukumoto, H., et al. 2002. J. Biol. Chem. 277, 48508.
DeBose-Boyd, R.A., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 1477.
Repa, J.J., et al. 2000. Science 289, 1524.
Schultz, J.R., et al. 2000. Genes Dev. 14, 2831.
Product Information
CAS number293754-55-9
ATP CompetitiveN
FormLight beige solid
Hill FormulaC₁₇H₁₂NSO₃F₉
Chemical formulaC₁₇H₁₂NSO₃F₉
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetLiver X receptor (LXRα)
Primary Target IC<sub>50</sub>EC50 = 20 nM for LXRα
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Harmful
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
575310-10MG 04055977189254

Documentation

T0901317 - CAS 293754-55-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

T0901317 - CAS 293754-55-9 - Calbiochem Certificates of Analysis

TitleLot Number
575310

References

Reference overview
Terasaka, N., et al. 2003. FEBS Lett. 536, 6.
Cao, G., et al. 2002. J. Biol. Chem. 278, 1131.
Field, F.J., et al. 2002. Biochem. J. 368, 855.
Fukumoto, H., et al. 2002. J. Biol. Chem. 277, 48508.
DeBose-Boyd, R.A., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 1477.
Repa, J.J., et al. 2000. Science 289, 1524.
Schultz, J.R., et al. 2000. Genes Dev. 14, 2831.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision22-May-2014 JSW
SynonymsTO-901317, N-(2,2,2-Trifluoroethyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]sulfonamide
DescriptionA cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC50 = 20 nM for LXRα). Reported to induce the expression of genes associated with fatty acid biosynthesis. Raises the levels of serum HDL cholesterol and triglycerides in mice and inhibits the development of atherosclerosis in LDL receptor-deficient mice. Also shown to lower plasma glucose levels in diabetic rodents.
FormLight beige solid
Intert gas (Yes/No) Packaged under inert gas
CAS number293754-55-9
Chemical formulaC₁₇H₁₂NSO₃F₉
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml) or Ethanol (50 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
ReferencesTerasaka, N., et al. 2003. FEBS Lett. 536, 6.
Cao, G., et al. 2002. J. Biol. Chem. 278, 1131.
Field, F.J., et al. 2002. Biochem. J. 368, 855.
Fukumoto, H., et al. 2002. J. Biol. Chem. 277, 48508.
DeBose-Boyd, R.A., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 1477.
Repa, J.J., et al. 2000. Science 289, 1524.
Schultz, J.R., et al. 2000. Genes Dev. 14, 2831.