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569615 Stem-Cell Factor/c-Kit Inhibitor, ISCK03 - CAS 945526-43-2 - Calbiochem

The Stem-Cell Factor/c-Kit Inhibitor, ISCK03, also referenced under CAS 945526-43-2, controls the biological activity of Stem-Cell Factor/c-Kit. This small molecule/inhibitor is primarily used for Pho

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MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-t-Butylphenyl-N-(4-imidazol-1-yl-phenyl)sulfonamide, SCF/c-Kit Signaling Inhibitor, ISCK03, c-Kit Inhibitor II

569615
  
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Overview

Key Spec Table

CAS #Empirical Formula
945526-43-2C₁₉H₂₁N₃O₂S
Description
Overview

This product has been discontinued.



A cell-permeable phenyl-imidazolosulfonamide compound that inhibits c-kit activity (IC50 <<2.5 µM in cell-free kinase assays) and blocks SCF-induced c-kit and Erk phosphorylation (1 µM causes >90% inhibition) without any effect on HGF-induced Erk phosphorylation in 501mel melanoma cells. Oral administration of ISCK03 is shown to induce hair depigmentation in C57BL/6 mice in a dose-dependent and reversible manner. Topical application is likewise demonstrated to decrease UV-induced pigmentation and epidermal melanin level in Brownish guinea pigs in vivo.
Catalogue Number569615
Brand Family Calbiochem®
Synonyms4-t-Butylphenyl-N-(4-imidazol-1-yl-phenyl)sulfonamide, SCF/c-Kit Signaling Inhibitor, ISCK03, c-Kit Inhibitor II
References
ReferencesNa, Y.J., et al. 2007. Biochem. Pharmacol. 74, 780.
Product Information
CAS number945526-43-2
FormDark yellow solid
Hill FormulaC₁₉H₂₁N₃O₂S
Chemical formulaC₁₉H₂₁N₃O₂S
Structure formula ImageStructure formula Image
Biological Information
Purity≥97% by HPLC
Safety Information
S PhraseS: 22-24/25-36-45

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
569615 0