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559307 Sangivamycin - CAS 18417-89-5 - Calbiochem

Sangivamycin - CAS 18417-89-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 7-Deaza-7-carbamoyladenosine, NSC-65346

Primary Target: PKC
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
18417-89-5C₁₂H₁₅N₅O₅
Description
Overview

This product has been discontinued.



A cytotoxic purine nucleoside active against human cytomegalovirus (HCMV). A cell-permeable, reversible, selective, and potent protein kinase C (PKC) inhibitor (IC50 = 10 µM). The inhibition is competitive with respect to ATP and non-competitive with respect to histone and lipid cofactors.
Catalogue Number559307
Brand Family Calbiochem®
Synonyms7-Deaza-7-carbamoyladenosine, NSC-65346
References
ReferencesGreene, N.M., et al. 1995. J. Biol. Chem. 270, 6710.
Osada, H., et al. 1989. J. Antibiot. 42, 402.
Loomis, C.R. and Bell, R.M. 1988. J. Biol. Chem. 263, 1682.
Turk, S.R., et al. 1987. Antimicrob. Agents Chemother. 31, 544.
Product Information
CAS number18417-89-5
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₂H₁₅N₅O₅
Chemical formulaC₁₂H₁₅N₅O₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPKC
Primary Target IC<sub>50</sub>10 µM against PKC
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSUY9355000
Safety Information
R PhraseR: 26/27/28

Very toxic by inhalation, in contact with skin and if swallowed.
S PhraseS: 36/37/39-45

Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Highly Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
559307 0

Documentation

Sangivamycin - CAS 18417-89-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Sangivamycin - CAS 18417-89-5 - Calbiochem Certificates of Analysis

TitleLot Number
559307

References

Reference overview
Greene, N.M., et al. 1995. J. Biol. Chem. 270, 6710.
Osada, H., et al. 1989. J. Antibiot. 42, 402.
Loomis, C.R. and Bell, R.M. 1988. J. Biol. Chem. 263, 1682.
Turk, S.R., et al. 1987. Antimicrob. Agents Chemother. 31, 544.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-January-2010 RFH
Synonyms7-Deaza-7-carbamoyladenosine, NSC-65346
DescriptionA cytotoxic purine nucleoside active against human cytomegalovirus (HCMV). A cell-permeable, reversible, selective, and potent protein kinase C (PKC) inhibitor (IC50 = 10 µM). The inhibition is competitive with respect to ATP and non-competitive with respect to histone and lipid cofactors.
FormWhite solid
CAS number18417-89-5
RTECSUY9355000
Chemical formulaC₁₂H₁₅N₅O₅
Structure formulaStructure formula
Purity≥98% by HPLC
Solubility0.1 M KOH (5 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Highly Toxic
ReferencesGreene, N.M., et al. 1995. J. Biol. Chem. 270, 6710.
Osada, H., et al. 1989. J. Antibiot. 42, 402.
Loomis, C.R. and Bell, R.M. 1988. J. Biol. Chem. 263, 1682.
Turk, S.R., et al. 1987. Antimicrob. Agents Chemother. 31, 544.