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559405 SB 225002 - CAS 182498-32-4 - Calbiochem

A potent, selective, and competitive antagonist of the G-protein coupled receptor CXCR2 (IL-8RB; IC₅₀ = 22 nM for the inhibition of ¹²⁵I-IL-8 binding to CXCR2).

SB 225002 - CAS 182498-32-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(2-Hydroxy-4-nitrophenyl)-Nʹ-(2-bromophenyl)urea, CXCR2 Antagonist II

Primary Target: CXCR2
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
182498-32-4C₁₃H₁₀BrN₃O₄

Products

Catalogue NumberPackaging Qty/Pack
559405-1MG Glass bottle 1 mg
Description
OverviewA potent, selective, and competitive antagonist of the G-protein coupled receptor CXCR2 (IL-8RB; IC50 = 22 nM for the inhibition of 125I-IL-8 binding to CXCR2). Shows ~150-fold selectivity over CXCR1. Inhibits human and rabbit neutrophil chemotaxis induced by both IL-8 and GROα in vitro and in vivo selectively blocks IL-8-induced neutrophil margination in rabbits. Reduces presenilin expression, inhibits γ-secretase activity, and blocks Aβ40/42 production and notch processing; further, demonstrates in vivo efficacy in mouse models.
Catalogue Number559405
Brand Family Calbiochem®
SynonymsN-(2-Hydroxy-4-nitrophenyl)-Nʹ-(2-bromophenyl)urea, CXCR2 Antagonist II
References
ReferencesBakshi, P., et al. 2009. ACS Chem. Biol. in press.
White, J.R., et al. 1998. J. Biol. Chem. 273, 10095.
Product Information
CAS number182498-32-4
ATP CompetitiveN
FormYellow solid
Hill FormulaC₁₃H₁₀BrN₃O₄
Chemical formulaC₁₃H₁₀BrN₃O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCXCR2
Primary Target IC<sub>50</sub>22 nM for the inhibition of 125I-IL-8 binding to CXCR2
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
559405-1MG 04055977191967

Documentation

SB 225002 - CAS 182498-32-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

SB 225002 - CAS 182498-32-4 - Calbiochem Certificates of Analysis

TitleLot Number
559405

References

Reference overview
Bakshi, P., et al. 2009. ACS Chem. Biol. in press.
White, J.R., et al. 1998. J. Biol. Chem. 273, 10095.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-April-2011 RFH
SynonymsN-(2-Hydroxy-4-nitrophenyl)-Nʹ-(2-bromophenyl)urea, CXCR2 Antagonist II
DescriptionA potent and selective antagonist of G-protein coupled receptor CXCR2 (IL-8RB; IC50 = 22 nM for the inhibition of 125I-IL-8 binding to CXCR2). Inhibits human and rabbit neutrophil chemotaxis induced by both IL-8 and GROα in vitro and selectively blocks IL-8-induced neutrophil margination in rabbits. Reduces presenilin expression, inhibits γ-secretase activity, and blocks Aβ40/42 production and notch processing; further, demonstrates in vivo efficacy in mouse models.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number182498-32-4
Chemical formulaC₁₃H₁₀BrN₃O₄
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (200 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBakshi, P., et al. 2009. ACS Chem. Biol. in press.
White, J.R., et al. 1998. J. Biol. Chem. 273, 10095.