559389 Sigma-AldrichSB 203580 - CAS 152121-47-6 - Calbiochem
SB 203580, CAS 152121-47-6, is a highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 MAP kinase (IC₅₀ = 34 nM in vitro, 600 nM in cells).
More>> SB 203580, CAS 152121-47-6, is a highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 MAP kinase (IC₅₀ = 34 nM in vitro, 600 nM in cells). Less<<Synonyms: 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole, p38 MAP Kinase Inhibitor XVI
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Overview
Key Spec Table
CAS # | Empirical Formula |
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152121-47-6 | C₂₁H₁₆N₃OSF |
Products
Catalogue Number | Packaging | Qty/Pack | |
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559389-10MG | Glass bottle | 10 mg | |
559389-1MG | Plastic ampoule | 1 mg | |
559389-5MG | Glass bottle | 5 mg |
Description | |
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Overview | Reduces epirubicin-induced cell injury and caspase-3/7 activity. A highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 MAP kinase (IC50 = 34 nM in vitro, 600 nM in cells). Does not significantly inhibit the JNK and p42 MAP kinase at 100 µM. Inhibits IL-1 and TNF-α production from LPS-stimulated human monocytes and the human monocyte cell line THP-1 (IC50 = 50-100 nM). Inhibits bone morphogenetic protein-2-induced neurite outgrowth in PC12 cells. Also inhibits platelet aggregation caused by collagen (IC50 = 0.2-1.0 µM) or the thromboxane analog U-46619 (Cat. No. 538944). A 1 mg/ml solution of SB 203580 (Cat. No. 559398) in anhydrous DMSO is also available. |
Catalogue Number | 559389 |
Brand Family | Calbiochem® |
Synonyms | 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole, p38 MAP Kinase Inhibitor XVI |
Product Information | |
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CAS number | 152121-47-6 |
ATP Competitive | Y |
Form | Thin film |
Hill Formula | C₂₁H₁₆N₃OSF |
Chemical formula | C₂₁H₁₆N₃OSF |
Reversible | Y |
Structure formula Image | |
Quality Level | MQ100 |
Physicochemical Information | |
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Cell permeable | Y |
Global Trade Item Number | |
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Catalogue Number | GTIN |
559389-10MG | 04055977192490 |
559389-1MG | 07790788051532 |
559389-5MG | 04055977192537 |