Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

557362 Roscovitine, (S)-Isomer - CAS 186692-45-5 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(S)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine, Cdk7 Inhibitor I, (S)-Isomer

Primary Target: p34cdk1/cyclin B kinase
View Products on Sigmaaldrich.com
557362
  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
186692-45-5C₁₉H₂₆N₆O
Description
Overview

This product has been discontinued.



The (S)-enantiomer of the potent cyclin-dependent kinase (Cdk) inhibitor Roscovitine (Cat. No. 557360). Potently inhibits p34cdk1/cyclin B kinase (IC50 = 800 nM).
Catalogue Number557362
Brand Family Calbiochem®
Synonyms2-(S)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine, Cdk7 Inhibitor I, (S)-Isomer
References
ReferencesHavlicek, L., et al. 1997. J. Med. Chem. 40, 408.
Product Information
CAS number186692-45-5
ATP CompetitiveN
DeclarationSold under license of U.S. Patent 6,316,456.
FormWhite solid
Hill FormulaC₁₉H₂₆N₆O
Chemical formulaC₁₉H₂₆N₆O
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetp34cdk1/cyclin B kinase
Primary Target IC<sub>50</sub>800 nM against p34cdk1/cyclin B kinase
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
557362 0

Documentation

Roscovitine, (S)-Isomer - CAS 186692-45-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Roscovitine, (S)-Isomer - CAS 186692-45-5 - Calbiochem Certificates of Analysis

TitleLot Number
557362

References

Reference overview
Havlicek, L., et al. 1997. J. Med. Chem. 40, 408.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-April-2011 RFH
Synonyms2-(S)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine, Cdk7 Inhibitor I, (S)-Isomer
DescriptionThe (S)-enantiomer of the potent cyclin-dependent kinase (cdk) inhibitor Roscovitine (Cat. No. 557360). Potently inhibits p34cdc2/cyclin B kinase (IC50 = 800 nM).
FormWhite solid
CAS number186692-45-5
Chemical formulaC₁₉H₂₆N₆O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesHavlicek, L., et al. 1997. J. Med. Chem. 40, 408.