Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

555558 Rho/SRF Pathway Inhibitor, CCG-1423 - CAS 285986-88-1 - Calbiochem

The Rho/SRF Pathway Inhibitor, CCG-1423, also referenced under CAS 285986-88-1, controls the biological activity of Rho/SRF. This small molecule/inhibitor is primarily used for Cell Structure applicat

 More>>
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(2-(4-Chloroanilino)-1-methyl-2-oxoethoxy)-3,5-bis(trifluoromethyl)benzamide, MICAL-2 Inhibitor I, MRTF-A/SRF Transcription Inhibitor I, MLK1/SRF Transcription Inhibitor I

View Products on Sigmaaldrich.com
555558
Purchase on Sigma-Aldrich

Overview

Key Spec Table

CAS #Empirical Formula
285986-88-1C₁₈H₁₃ClF₆N₂O₃

Products

Catalogue NumberPackaging Qty/Pack
555558-25MG Glass bottle 25 mg
Add To Favorites
Description
OverviewA cell-permeable benzamide compound that acts as an effective inhibitor against RhoA- and RhoC-mediated cellular activities by targeting signaling events downstream of Gα12/13 and RhoA/C, affecting MKL recruitment and/or postrecruitment function of MKL1, but not SRF-SRE interaction or ROCK kinase activity. CCG-1423 is shown to inhibit RhoC-dependent cell growth in A375M2 and SK-Mel-147 (IC50 ≤300 nM) and block RhoC/ Gα12-mediated PC-13 invasion in Matrigel assays (by ~90% at 3 µM). Shown to inhibit MICAL-2 with a Ki of 1.5 µM.
Catalogue Number555558
Brand Family Calbiochem®
SynonymsN-(2-(4-Chloroanilino)-1-methyl-2-oxoethoxy)-3,5-bis(trifluoromethyl)benzamide, MICAL-2 Inhibitor I, MRTF-A/SRF Transcription Inhibitor I, MLK1/SRF Transcription Inhibitor I
References
ReferencesLundquist, M.R., et al. 2014. Cell 156, 563..
Evelyn, C.R., et al. 2007. Mol. Cancer Ther. 6, 2249.
Product Information
CAS number285986-88-1
FormWhite solid
Hill FormulaC₁₈H₁₃ClF₆N₂O₃
Chemical formulaC₁₈H₁₃ClF₆N₂O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥95% by HPLC
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
555558-25MG 04055977268478