Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

554328 Resveratrol, Triacetyl - CAS 42206-94-0 - Calbiochem

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
42206-94-0C₂₀H₁₈O₈

Products

Catalogue NumberPackaging Qty/Pack
554328-25MG Glass bottle 25 mg
Description
OverviewA cell-permeable triacetate resveratrol (Cat. No. 554325) prodrug that is easily converted to resveratrol by esterase activity and exhibits similar bioactivity as resveratrol in cell cultures. Cremophor EL is reported to protect the prodrug from fast hydrolysis and resveratrol conversion in mouse serum at 37°C (100% conversion within 20 sec vs. >300 min or T1/2 of 48 min delivered with DMSO or 1:1:8 (v/v/v) EtOH/Cremophor EL/H2O, respectively; [prodrug]t=0 = 100 µM), although the active drug resveratrol is stable for more than 27 h under the same condition without Cremophor EL. When dosed at 10 mg/kg and delivered with 1:1:8 (v/v/v) EtOH/Cremophor EL/H2O intraperitoneally before, but not after, exposure to lethal γ-irradiation (9.75 Gy), the prodrug, but not resveratrol, is shown to greatly prevent irradiation-induced death in mice in vivo (survival rate = 77.4% with 10 mg/kg prodrug vs. ≤28.3% with 10 mg/kg resveratrol, vehicle alone, or no pretreatment at all).
Catalogue Number554328
Brand Family Calbiochem®
Synonymstrans-3,5,4ʹ-Triacetylstilbene, 3,5,4ʹ-Tri-O-acetylresveratrol
References
ReferencesKoide, K., et al. 2011. ACS Med. Chem. Lett. 2, 270.
Hsieh, T.C., et al. 2011. Int. J. Cancer 129, 2732.
Product Information
CAS number42206-94-0
FormWhite powder
Hill FormulaC₂₀H₁₈O₈
Chemical formulaC₂₀H₁₈O₈
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Regulatory Review
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
554328-25MG 04055977193060

Documentation

Resveratrol, Triacetyl - CAS 42206-94-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Resveratrol, Triacetyl - CAS 42206-94-0 - Calbiochem Certificates of Analysis

TitleLot Number
554328

References

Reference overview
Koide, K., et al. 2011. ACS Med. Chem. Lett. 2, 270.
Hsieh, T.C., et al. 2011. Int. J. Cancer 129, 2732.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-December-2011 RFH
Synonymstrans-3,5,4ʹ-Triacetylstilbene, 3,5,4ʹ-Tri-O-acetylresveratrol
DescriptionA cell-permeable triacetate resveratrol (Cat. No. 300 min or T1/2 of 48 min delivered with DMSO or 1:1:8 (v/v/v) EtOH/Cremophor EL/H2O, respectively; [prodrug]t=0 = 100 µM), although the active drug resveratrol is stable for more than 27 h under the same condition without Cremophor EL. When dosed at 10 mg/kg and delivered with 1:1:8 (v/v/v) EtOH/Cremophor EL/H2O intraperitoneally before, but not after, exposure to lethal γ-irradiation (9.75 Gy), the prodrug, but not resveratrol, is shown to greatly prevent irradiation-induced death in mice in vivo (survival rate = 77.4% with 10 mg/kg prodrug vs. ≤28.3% with 10 mg/kg resveratrol, vehicle alone, or no pretreatment at all).
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
CAS number42206-94-0
Chemical formulaC₂₀H₁₈O₈
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Regulatory Review
ReferencesKoide, K., et al. 2011. ACS Med. Chem. Lett. 2, 270.
Hsieh, T.C., et al. 2011. Int. J. Cancer 129, 2732.