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557451 RXRα Inhibitor, K-80003 - Calbiochem

The RXRα Inhibitor, K-80003 controls the biological activity of RXRα. This small molecule/inhibitor is primarily used for Cell Signaling applications.

RXRα Inhibitor, K-80003 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: K-80003

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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₂H₂₁FO₂
Description
OverviewA cell permeable, Sulindac analog with IC50=2.4 µM for RXRα binding, and unlike other NSAIDs, is inactive toward COX2 and COX1 even at 1 mM. The compound displays potent inhibition of RXRα dependent AKT Activation in both PC3 and A549 cells, and is RXRα but not RXRγ expression dependent as shown in PC3 cells. It is further shown to inhibit the interaction of RXRα/Δ80 with p85α either in the absence or presence of TNF-α. Induces PARP cleavage and caspase-8 activation at 50 µM when used with TNF-α. Furthermore, it almost completely suppresses colony formation of HeLa/RXRα/1-134 and RXRα/Δ80 cells at 25 µM in vitro, and exhibits potent inhibition of tumor growth in vivo when dosed at 60mg/kg.
Catalogue Number557451
Brand Family Calbiochem®
SynonymsK-80003
References
ReferencesZhou, H., et al. 2010. Cancer Cell 17, 560.
Product Information
FormYellow solid
Hill FormulaC₂₂H₂₁FO₂
Chemical formulaC₂₂H₂₁FO₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
557451 0

Documentation

RXRα Inhibitor, K-80003 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

RXRα Inhibitor, K-80003 - Calbiochem Certificates of Analysis

TitleLot Number
557451

References

Reference overview
Zhou, H., et al. 2010. Cancer Cell 17, 560.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-July-2023 JSW
SynonymsK-80003
DescriptionA cell permeable, Sulindac analog with IC50=2.4 µM for RXRα binding, and unlike other NSAIDs, is inactive toward COX2 and COX1 even at 1 mM. The compound displays potent inhibition of RXRα dependent AKT Activation in both PC3 and A549 cells, and is RXRα but not RXRγ expression dependent as shown in PC3 cells. It is further shown to inhibit the interaction of RXRα/Δ80 with p85α either in the absence or presence of TNF-α. Induces PARP cleavage and caspase-8 activation at 50 µM when used with TNF-α. Furthermore, it almost completely suppresses colony formation of HeLa/RXRα/1-134 and RXRα/Δ80 cells at 25 µM in vitro, and exhibits potent inhibition of tumor growth in vivo when dosed at 60 mg/kg.
FormYellow solid
Chemical formulaC₂₂H₂₁FO₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C.
Toxicity Standard Handling
ReferencesZhou, H., et al. 2010. Cancer Cell 17, 560.