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557401 RNA-Editing Ligase 1 Inhibitor, NSC 45208

The RNA-Editing Ligase 1 Inhibitor, NSC 45208 controls the biological activity of RNA-Editing Ligase 1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

RNA-Editing Ligase 1 Inhibitor, NSC 45208 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4,5-Dihydroxy-3-(1-naphthyldiazenyl)-2,7-naphthalenedisulfonic acid, disodium salt, dihydrate, REL1 Inhibitor

557401
  
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₀H₁₂N₂Na₂O₈S₂ • 4H₂O
Description
Overview

This product has been discontinued.





A sulfonated azo dye, initially identified by a Trypanosoma burcei RNA-editing ligase 1 (TbREL1) crystal structure-based inhibitor screening, is shown to inhibit TbREL1 activity (IC50 = 1.95 µM) by targeting the enzyme's ATP binding pocket. V1 is less potent against T4 phage RNA ligase 2 and human DNA ligase IIIβ (IC50 = 3.53 and 27.49 µM, respectively).
Catalogue Number557401
Brand Family Calbiochem®
Synonyms4,5-Dihydroxy-3-(1-naphthyldiazenyl)-2,7-naphthalenedisulfonic acid, disodium salt, dihydrate, REL1 Inhibitor
References
ReferencesAmaro, R.E., et al. 2008. Proc. Natl. Acad. Sci. USA 105, 17278.
Product Information
FormDark red solid
Hill FormulaC₂₀H₁₂N₂Na₂O₈S₂ • 4H₂O
Chemical formulaC₂₀H₁₂N₂Na₂O₈S₂ • 4H₂O
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥95% based on elemental analysis
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +15°C to +30°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
557401 0

Documentation

RNA-Editing Ligase 1 Inhibitor, NSC 45208 Certificates of Analysis

TitleLot Number
557401

References

Reference overview
Amaro, R.E., et al. 2008. Proc. Natl. Acad. Sci. USA 105, 17278.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-August-2009 RFH
Synonyms4,5-Dihydroxy-3-(1-naphthyldiazenyl)-2,7-naphthalenedisulfonic acid, disodium salt, dihydrate, REL1 Inhibitor
DescriptionA sulfonated azo dye, initially identified by a Trypanosoma burcei RNA-editing ligase 1 (TbREL1) crystal structure-based inhibitor screening, is shown to inhibit TbREL1 activity (IC50 = 1.95 µM) by targeting the enzyme's ATP binding pocket. V1 is less potent against T4 phage RNA ligase 2 and human DNA ligase IIIβ (IC50 = 3.53 and 27.49 µM, respectively).
FormDark red solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₀H₁₂N₂Na₂O₈S₂ • 4H₂O
Structure formulaStructure formula
Purity≥95% based on elemental analysis
SolubilityDMSO (10 mg/ml) or H₂O (1 mg/ml)
Storage Protect from light
+15°C to +30°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesAmaro, R.E., et al. 2008. Proc. Natl. Acad. Sci. USA 105, 17278.