500502 Sigma-AldrichProteasome Inhibitor XXI, Z-LLLL-SF - CAS 1415548-57-0 - Calbiochem
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Primary Target:
β5 chymotrypsin-like activity of 20S proteasome
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Cbz-Leu-Leu-Leu-Leu-ψ-[CH2SO2]-F, Cbz-Leu₄-SF, Cbz-LLLL-SF, Z-Leu₄-SF, Z-L₄-SF
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 1415548-57-0 | C₃₂H₅₃FN₄O₇S |
| Description | |
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| Overview | A cell-permeable tetrapeptidylsulfonylfluoride-based irreversible proteasome inhibitor that selectively inhibits the hydrolysis of Suc-LLVY-AMC (Cat. No. 539142) by the β5 chymotrypsin-like activity (IC50 = 7 nM using yeast 20S proteasome), while exhibiting much reduced potency against Z-LLE-AMC (Cat. No. 539141) hydrolysis by the β1 caspase-like activity or Z-LLR-AMC hydrolysis by the β2 trypsin-like activity (29% and 75% inhibition, respectively, with 200 µM inhibitor). One hour inhibitor treatment at 5 µM in HEK cultures is shown to completely abolish β5 labeling by the proteasome probe MV151, while only partial MV151 blockage is seen with β1 and β2 at an inhibitor concentration of 50 µM. Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water. |
| Catalogue Number | 500502 |
| Brand Family | Calbiochem® |
| Synonyms | Cbz-Leu-Leu-Leu-Leu-ψ-[CH2SO2]-F, Cbz-Leu₄-SF, Cbz-LLLL-SF, Z-Leu₄-SF, Z-L₄-SF |
| References | |
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| References | Brouwer. A.J., et al. 2013. J. Med. Chem. 55, 10995. |
| Product Information | |
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| CAS number | 1415548-57-0 |
| Form | White powder |
| Hill Formula | C₃₂H₅₃FN₄O₇S |
| Chemical formula | C₃₂H₅₃FN₄O₇S |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | β5 chymotrypsin-like activity of 20S proteasome |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Safety Information according to GHS |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 500502 | 0 |
Documentation
Proteasome Inhibitor XXI, Z-LLLL-SF - CAS 1415548-57-0 - Calbiochem SDS
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References
| Reference overview |
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| Brouwer. A.J., et al. 2013. J. Med. Chem. 55, 10995. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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