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537011 Prolyl Endopeptidase Inhibitor II - CAS 108708-25-4 - Calbiochem

The Prolyl Endopeptidase Inhibitor II, also referenced under CAS 108708-25-4, controls the biological activity of Prolyl Endopeptidase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Z-PP-CHO

Primary Target: Mouse brain prolylendooeotidase
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
108708-25-4C₁₈H₂₂N₂O₄
Description
OverviewA cell-permeable dipeptide aldehyde that acts as a specific, potent, slow, and tight-binding transition state analog inhibitor of prolyl endopeptidase (Ki = 350 pM and 500 pM for mouse brain and human brain, respectively). Reported to form a hemiacetal with the active site serine of the enzyme.
Catalogue Number537011
Brand Family Calbiochem®
SynonymsZ-PP-CHO
References
ReferencesFülöp, V., et al. 1998. Cell 94, 161.
Kahyaoglu, A., et al. 1997. Biochem. J. 322, 839.
Bakker, A.V., et al. 1990. Biochem. J. 271, 559.
Wilk, S., and Orlowski, M. 1983. J. Neurochem. 41, 69.
Product Information
CAS number108708-25-4
ATP CompetitiveN
FormColorless to off-white oil
Hill FormulaC₁₈H₂₂N₂O₄
Chemical formulaC₁₈H₂₂N₂O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMouse brain prolylendooeotidase
Primary Target K<sub>i</sub>350 pM and 500 pM for mouse brain and human brain prolyl endopeptidase, respectively
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceZ-Pro-Pro-CHO
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
537011 0

Documentation

Prolyl Endopeptidase Inhibitor II - CAS 108708-25-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Prolyl Endopeptidase Inhibitor II - CAS 108708-25-4 - Calbiochem Certificates of Analysis

TitleLot Number
537011

References

Reference overview
Fülöp, V., et al. 1998. Cell 94, 161.
Kahyaoglu, A., et al. 1997. Biochem. J. 322, 839.
Bakker, A.V., et al. 1990. Biochem. J. 271, 559.
Wilk, S., and Orlowski, M. 1983. J. Neurochem. 41, 69.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-November-2011 JSW
SynonymsZ-PP-CHO
DescriptionA cell-permeable dipeptide aldehyde that acts as a specific, potent, slow and tight-binding transition state analog inhibitor of prolyl endopeptidase (Ki = 350 pM and 500 pM for mouse brain and human brain prolyl endopeptidase, respectively). Reported to form a hemiacetal with the active-site serine.
FormColorless to off-white oil
Intert gas (Yes/No) Packaged under inert gas
CAS number108708-25-4
Chemical formulaC₁₈H₂₂N₂O₄
Peptide SequenceZ-Pro-Pro-CHO
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (10 mg/ml), DMF, ethyl acetate
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesFülöp, V., et al. 1998. Cell 94, 161.
Kahyaoglu, A., et al. 1997. Biochem. J. 322, 839.
Bakker, A.V., et al. 1990. Biochem. J. 271, 559.
Wilk, S., and Orlowski, M. 1983. J. Neurochem. 41, 69.