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524403 Pravastatin, Sodium Salt - CAS 81131-70-6 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
81131-70-6C₂₃H₃₅O₇.Na

Products

Catalogue NumberPackaging Qty/Pack
524403-25MG Plastic Bag(s) 25 mg
Description
OverviewA water-soluble, competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that potently blocks in vivo cholesterol synthesis (Ki = ~1 nM). Offers cardioprotection. Also acts as an immunomodulator and an inhibitor of ras p21 isoprenylation.
Catalogue Number524403
Brand Family Calbiochem®
Synonyms(βR,δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β,δ,6-trihydroxy-2-methyl-8[(2S)-2-methyl-1-oxobutoxyl]-1-naphthaleneheptanoic Acid Na, 3β-Hydroxycompactin, Na
References
ReferencesKwak, B., et al. 2000. Natl. Med. 6, 1399.
Hamelin, B.A., and Turgeon, J., 1998. Trends Pharmacol. Sci. 19, 26.
Narisawa, T., et al. 1996. Jpn. J. Cancer Res. 87, 798.
Cohen, L.H., et al. 1993. Biochem. Pharmacol. 45, 2203.
Koga, T., et al. 1990. Biochim. Biophys. Acta. 1045, 115.
Yoshino, G., et al. 1986. Diabetes Res. Clin. Pract. 2, 179
Product Information
CAS number81131-70-6
ATP CompetitiveN
FormWhite crystalline solid
Hill FormulaC₂₃H₃₅O₇.Na
Chemical formulaC₂₃H₃₅O₇.Na
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetAMG-CoA reductase
Primary Target K<sub>i</sub>~1 nM inhibiting 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and blocking in vivo cholesterol synthesis
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Safety Information according to GHS
RTECSQJ7185000
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Environmental Hazard
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
524403-25MG 04055977270983