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506152 Pifithrin-α, p-Nitro

Pifithrin-α, p-Nitro MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-(4-Nitrophenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone, HBr

506152
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
389850-21-9C₁₅H₁₅N₃O₃S • HBr
Description
Overview

This product has been discontinued.





A cell-permeable p53 inhibitor that serves as the prodrug form of Pifithrin-α, p-Nitro, Cyclic (Cat. No. 506154). Although its in vitro efficacy (ED50 = 0.3 µM in protecting etoposide-induced cortical neuron death) is similar to that of Pifithrin-α (Cat. No. 506132), it is 100-fold more potent than Pifithrin-α when adminstered in rats in vivo due to its long-lasting, steady conversion to the corresponding cyclic form of active compound in biological systems (t1/2 = 8h in neuron culture medium at 37°C).
Catalogue Number506152
Brand Family Calbiochem®
Synonyms1-(4-Nitrophenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone, HBr
References
ReferencesPietrancosta, N., et al. 2006. J. Med. Chem. 49, 3645.
Product Information
CAS number389850-21-9
FormBeige solid
Hill FormulaC₁₅H₁₅N₃O₃S • HBr
Chemical formulaC₁₅H₁₅N₃O₃S • HBr
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsUnstable in solution; reconstitute just prior to use.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
506152 0

Documentation

Pifithrin-α, p-Nitro Certificates of Analysis

TitleLot Number
506152

References

Reference overview
Pietrancosta, N., et al. 2006. J. Med. Chem. 49, 3645.

Brochure

Title
p53 And Related Products
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-April-2011 RFH
Synonyms1-(4-Nitrophenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone, HBr
DescriptionA cell-permeable p53 inhibitor that serves as the prodrug form of Pifithrin-α, p-Nitro, Cyclic (Cat. No. 506154). Although its in vitro efficacy (ED50 = 0.3 µM in protecting etoposide-induced cortical neuron death) is similar to that of Pifithrin-α (Cat. No. 506132), it is 100-fold more potent than Pifithrin-α when adminstered in rats in vivo due to its long-lasting, steady conversion to the corresponding cyclic form of active compound in biological systems (t1/2 = 8h in neuron culture medium at 37°C).
FormBeige solid
Intert gas (Yes/No) Packaged under inert gas
CAS number389850-21-9
Chemical formulaC₁₅H₁₅N₃O₃S • HBr
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (100 mg/ml) or Ethanol (2.5 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsUnstable in solution; reconstitute just prior to use.
Toxicity Standard Handling
ReferencesPietrancosta, N., et al. 2006. J. Med. Chem. 49, 3645.