516485 Sigma-AldrichPepstatin A Methyl Ester - Calbiochem
A cell-permeable methyl ester derivative of Pepstatin A that acts as a potent, non-competitive, transition-state analog inhibitor of γ-secretase.
More>> A cell-permeable methyl ester derivative of Pepstatin A that acts as a potent, non-competitive, transition-state analog inhibitor of γ-secretase. Less<<Pepstatin A Methyl Ester - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Isovaleryl-V V-Sta-A-Sta-OCH₃, PME
Recommended Products
Overview
| Replacement Information |
|---|
Key Spec Table
| Empirical Formula |
|---|
| C₃₅H₆₅N₅O₉ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 516485-1MG | Plastic ampoule | 1 mg |
| Description | |
|---|---|
| Overview | A cell-permeable methyl ester derivative of Pepstatin A (Cat. No. 516481) that acts as a potent, non-competitive, transition-state analog inhibitor of γ-secretase (Kis = 150 nM, Kii = 320 nM in solubilized human γ-secretase at 20°C; Kis is the inhibition constant for inhibitor binding to the free enzyme and Kii is the inhibition constant for inhibitor binding to the Enzyme-Substrate complex). Sta = (3S,4S)-4-Amino-3-hydroxy-6-methyl-heptanoic acid. |
| Catalogue Number | 516485 |
| Brand Family | Calbiochem® |
| Synonyms | Isovaleryl-V V-Sta-A-Sta-OCH₃, PME |
| References | |
|---|---|
| References | Tian, G., et al. 2002. J. Biol. Chem. 277, 31499. Zhang, L., et al. 2001. Biochemistry 40, 5049. Murphy, M.P., et al. 1999. J. Biol. Chem. 274, 11914. |
| Product Information | |
|---|---|
| ATP Competitive | N |
| Form | Lyophilized |
| Hill Formula | C₃₅H₆₅N₅O₉ |
| Chemical formula | C₃₅H₆₅N₅O₉ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
|---|
| Biological Information | |
|---|---|
| Primary Target | γ-secretase |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 516485-1MG | 07790788056308 |
Documentation
Pepstatin A Methyl Ester - Calbiochem SDS
| Title |
|---|
Pepstatin A Methyl Ester - Calbiochem Certificates of Analysis
| Title | Lot Number |
|---|---|
| 516485 |
References
| Reference overview |
|---|
| Tian, G., et al. 2002. J. Biol. Chem. 277, 31499. Zhang, L., et al. 2001. Biochemistry 40, 5049. Murphy, M.P., et al. 1999. J. Biol. Chem. 274, 11914. |