Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

540200 PTP Inhibitor I - CAS 2491-38-5 - Calbiochem

PTP Inhibitor I - CAS 2491-38-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Protein Tyrosine Phosphatase Inhibitor I, α-Bromo-4-hydroxyacetophenone, 4-Hydroxyphenacyl Br, SHP1 Inhibitor II

Primary Target: SHP-1
View Products on Sigmaaldrich.com
540200
  
Purchase on Sigma-Aldrich

Overview

Key Spec Table

CAS #Empirical Formula
2491-38-5C₈H₇BrO₂
Description
Overview

This product has been discontinued.



A potent, cell-permeable, and covalent protein tyrosine phosphatase (PTP) inhibitor. Inhibits SHP-1 (ΔSH2), the catalytic domain of the SH2 domain-containing phosphatase SHP-1 (Ki = 43 µM), and PTPIB (Ki = 42 µM). The inhibition can be reversed by irradiation of the inactivated PTP at 350 nm.
Catalogue Number540200
Brand Family Calbiochem®
SynonymsProtein Tyrosine Phosphatase Inhibitor I, α-Bromo-4-hydroxyacetophenone, 4-Hydroxyphenacyl Br, SHP1 Inhibitor II
References
ReferencesArabaci, G., et al. 1999. J. Am. Chem. Soc. 121, 5085.
Product Information
CAS number2491-38-5
ATP CompetitiveN
FormWhite powder
Hill FormulaC₈H₇BrO₂
Chemical formulaC₈H₇BrO₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetSHP-1
Primary Target IC<sub>50</sub>43 µM
Primary Target K<sub>i</sub>43 µM and 42 µM against SHP-1 and PTPIB, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Safety Information
R PhraseR: 34-36/37

Causes burns.
Irritating to eyes and respiratory system.
S PhraseS: 26-27-28-36/37/39

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Take off immediately all contaminated clothing.

Wear suitable protective clothing, gloves and eye/face protection.
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Corrosive
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage ≤ -70°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsUnstable in DMSO; reconstitute just prior to use.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
540200 0