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529570 PPM-18

PPM-18 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Benzoylamino-1,4-naphthoquinone

Primary Target: iNOS
529570
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
65240-86-0C₁₇H₁₁NO₃
Description
Overview

This product has been discontinued.



Please refer to our complete listing of nitric oxide synthase inhibitors for possible alternatives.






A novel, cell-permeable, anti-inflammatory agent that inhibits the expression of inducible nitric oxide synthase (iNOS; IC50 = ~ 5 µM). Acts by blocking the activation of NF-κB in vitro and in vivo. Does not directly affect the enzymatic activities of iNOS or eNOS.
Catalogue Number529570
Brand Family Calbiochem®
Synonyms2-Benzoylamino-1,4-naphthoquinone
References
ReferencesDavis, M.E., et al. 2004. J. Biol. Chem. 279, 163.
Yu, S.M., et al. 1997. Biochem. J. 328, 363.
Lien, J.-C., et al. 1996. Chem. Pharm. Bull. 44, 1181.
Product Information
CAS number65240-86-0
FormYellow-orange solid
Hill FormulaC₁₇H₁₁NO₃
Chemical formulaC₁₇H₁₁NO₃
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetiNOS
Primary Target IC<sub>50</sub>5 mM
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
529570 0

Documentation

PPM-18 Certificates of Analysis

TitleLot Number
529570

References

Reference overview
Davis, M.E., et al. 2004. J. Biol. Chem. 279, 163.
Yu, S.M., et al. 1997. Biochem. J. 328, 363.
Lien, J.-C., et al. 1996. Chem. Pharm. Bull. 44, 1181.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-April-2008 RFH
Synonyms2-Benzoylamino-1,4-naphthoquinone
DescriptionA cell-permeable naphthoquinone derivative that inhibits the expression of iNOS (IC50 ~5 µM) by blocking the activation of NF-κB in vitro and in vivo. Does not directly affect the enzymatic activities of iNOS or eNOS. Also prevents the dissociation of NF-κB/IκB-α complex and acts as a potent anti-inflammatory and anti-sepsis agent.
FormYellow-orange solid
Intert gas (Yes/No) Packaged under inert gas
CAS number65240-86-0
Chemical formulaC₁₇H₁₁NO₃
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (5 mg/ml) or CH₃CN (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesDavis, M.E., et al. 2004. J. Biol. Chem. 279, 163.
Yu, S.M., et al. 1997. Biochem. J. 328, 363.
Lien, J.-C., et al. 1996. Chem. Pharm. Bull. 44, 1181.