Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

508957 PDE5 Inhibitor, Cpd7a - CAS 1233518-60-9 - Calbiochem

A cell-permeable, highly potent and selective inhibitor of phosphodiesterase 5 (PDEV; IC₅₀ = 270 pM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: PDE5
View Products on Sigmaaldrich.com
508957
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1233518-60-9C₂₂H₂₀ClN₃O₂

Products

Catalogue NumberPackaging Qty/Pack
5.08957.0001 Glass bottle 5 mg
Description
OverviewA cell-permeable, brain permeant, quinoline-based compound that acts as a highly potent and selective inhibitor of phosphodiesterase 5 (PDEV; IC50 = 270 pM). Exhibits over 10,000 fold greater selectivity over various other phosphodiestrases and trivial activity against PDE VI (IC50 = 339 nM). Shown to increase cGMP levels in mouse hippocampus and attenuates long term potentiation and memory defects in mice with elevated levels of oligomeric Aβ42. It is rapidly absorbed with peak plasma concentration observed at 30 min. Displays desirable pharmacokinetic properties with plasma t1/2 = 1.33 h and brain t1/2 = 1.04 h.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number508957
Brand Family Calbiochem®
References
ReferencesFiorito, J., et al. 2013. Eur. J. Med. Chem. 60, 285.
Product Information
CAS number1233518-60-9
FormCream solid
Hill FormulaC₂₂H₂₀ClN₃O₂
Chemical formulaC₂₂H₂₀ClN₃O₂
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetPDE5
Primary Target IC<sub>50</sub>270 pM
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5.08957.0001 04055977261462

Documentation

PDE5 Inhibitor, Cpd7a - CAS 1233518-60-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Fiorito, J., et al. 2013. Eur. J. Med. Chem. 60, 285.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-April-2014 JSW
DescriptionA cell-permeable, brain permeant, quinoline-based compound that acts as a highly potent and selective inhibitor of phosphodiesterase 5 (PDEV; IC50 = 270 pM). Exhibits over 10,000 fold greater selectivity over various other phosphodiestrases and trivial activity against PDE VI (IC50 = 339 nM). Shown to increase cGMP levels in mouse hippocampus and attenuates long term potentiation and memory defects in mice with elevated levels of oligomeric Aβ42. It is rapidly absorbed with peak plasma concentration observed at 30 min. Displays desirable pharmacokinetic properties with plasma t1/2 = 1.33 h and brain t1/2 = 1.04 h.
FormCream solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1233518-60-9
Chemical formulaC₂₂H₂₀ClN₃O₂
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesFiorito, J., et al. 2013. Eur. J. Med. Chem. 60, 285.