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513033 PD 168393 - CAS 194423-15-9 - Calbiochem

PD 168393, CAS 194423-15-9, is a cell-permeable, potent, selective, irreversible, ATP-competitive inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 700 pM).

PD 168393 - CAS 194423-15-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline

Primary Target: EGFR
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
194423-15-9C₁₇H₁₃BrN₄O

Products

Catalogue NumberPackaging Qty/Pack
513033-1MG Plastic ampoule 1 mg
Description
OverviewA potent, cell-permeable, irreversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 700 pM). Does not inhibit other protein kinases. Acts by binding to the catalytic domain of the EGFR with a 1:1 stoichiometry and alkylating Cys773. Excellent antitumor agent in vivo.
Catalogue Number513033
Brand Family Calbiochem®
Synonyms4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline
References
ReferencesFry, D.W., et al. 1998. Proc. Natl. Acad. Sci USA 95, 12022.
Product Information
CAS number194423-15-9
ATP CompetitiveY
FormYellow solid
Hill FormulaC₁₇H₁₃BrN₄O
Chemical formulaC₁₇H₁₃BrN₄O
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationPD 168393, CAS 194423-15-9, is a cell-permeable, potent, selective, irreversible, ATP-competitive inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 700 pM).
Biological Information
Primary TargetEGFR
Primary Target IC<sub>50</sub>700 pM against EGFR
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
513033-1MG 04055977198638

Documentation

PD 168393 - CAS 194423-15-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

PD 168393 - CAS 194423-15-9 - Calbiochem Certificates of Analysis

TitleLot Number
513033

References

Reference overview
Fry, D.W., et al. 1998. Proc. Natl. Acad. Sci USA 95, 12022.

Posters

Title
Human Kinome & InhibitorSelect™ Libraries
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-April-2015 JSW
Synonyms4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline
DescriptionA potent, cell-permeable, irreversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 0.70 nM). Does not inhibit other protein kinases. Acts by binding to the catalytic domain of the EGFR with a 1:1 stoichiometry and alkylating Cys773. Excellent antitumor agent in vivo.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number194423-15-9
Chemical formulaC₁₇H₁₃BrN₄O
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (200 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
Toxicity Standard Handling
ReferencesFry, D.W., et al. 1998. Proc. Natl. Acad. Sci USA 95, 12022.