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488230 Nogo-66 (1-40) Antagonist Peptide, Synthetic - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Nogo Extracellular Peptide, 1-40, NEP1-40, Ac-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH₂

Primary Target: Nogo-66 receptor (NgR)
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₀₆H₃₂₄N₅₆O₆₅
Description
Overview

This product has been discontinued.



An end-protected 40-mer peptide derived from the N-terminal fragment of the Nogo-66 domain that acts as a selective, competitive, high affinity antagonist of Nogo-66 receptor (NgR). Although NgR serves as the common receptor for both Nogo-66 and MAG (myelin-associated glycoprotein), NEP1-40 blocks only the inhibition of neurite outgrowth induced by Nogo-66, but not that by MAG. Promotes axonal regeneration after spinal cord injury in rats.
Catalogue Number488230
Brand Family Calbiochem®
SynonymsNogo Extracellular Peptide, 1-40, NEP1-40, Ac-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH₂
References
ReferencesGrandPré, T., et al. 2002. Nature 417, 547.
Liu, B.P., et al. 2002. Science 297, 1190.
Product Information
ATP CompetitiveY
FormWhite solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₂₀₆H₃₂₄N₅₆O₆₅
Chemical formulaC₂₀₆H₃₂₄N₅₆O₆₅
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetNogo-66 receptor (NgR)
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceAc-Arg-Ile-Tyr-Lys-Gly-Val-Ile-Gln-Ala-Ile-Gln-Lys-Ser-Asp-Glu-Gly-His-Pro-Phe-Arg-Ala-Tyr-Leu-Glu-Ser-Glu-Val-Ala-Ile-Ser-Glu-Glu-Leu-Val-Gln-Lys-Tyr-Ser-Asn-Ser-NH₂
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
488230 0

Documentation

Nogo-66 (1-40) Antagonist Peptide, Synthetic - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Nogo-66 (1-40) Antagonist Peptide, Synthetic - Calbiochem Certificates of Analysis

TitleLot Number
488230

References

Reference overview
GrandPré, T., et al. 2002. Nature 417, 547.
Liu, B.P., et al. 2002. Science 297, 1190.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-August-2008 RFH
SynonymsNogo Extracellular Peptide, 1-40, NEP1-40, Ac-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH₂
DescriptionAn end-protected 40 amino acid peptide derived from the N-terminal fragment of the Nogo-66 domain that is normally expressed on the surface of oligodendrocytes. Acts as a selective, competitive, high affinity antagonist of Nogo-66 receptor (NgR). Although NgR serves as the common receptor for both Nogo-66 and myelin-associated glycoprotein (MAG), NEP1-40 blocks the inhibition of Nogo-66-induced neurite outgrowth, but not that of MAG. Promotes axonal regeneration following spinal cord injury in rats.
FormWhite solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₀₆H₃₂₄N₅₆O₆₅
Peptide SequenceAc-Arg-Ile-Tyr-Lys-Gly-Val-Ile-Gln-Ala-Ile-Gln-Lys-Ser-Asp-Glu-Gly-His-Pro-Phe-Arg-Ala-Tyr-Leu-Glu-Ser-Glu-Val-Ala-Ile-Ser-Glu-Glu-Leu-Val-Gln-Lys-Tyr-Ser-Asn-Ser-NH₂
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesGrandPré, T., et al. 2002. Nature 417, 547.
Liu, B.P., et al. 2002. Science 297, 1190.