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492030 NS 2028 - CAS 204326-43-2 - Calbiochem

Potent, specific, and irreversible inhibitor of soluble guanylyl cyclase.

NS 2028 - CAS 204326-43-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4H-8-Bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one

Primary Target: basal soluble guanylyl cyclase
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
204326-43-2C₉H₅BrN₂O₃

Products

Catalogue NumberPackaging Qty/Pack
492030-5MG Plastic ampoule 5 mg
Description
OverviewPotent, specific, and irreversible inhibitor of soluble guanylyl cyclase (IC50 = 30 nM for basal and 200 nM for NO-stimulated enzyme activity; IC50 = 17 nM for S-nitrosoglutathione-enhanced soluble guanylyl cyclase activity in homogenates of mouse cerebellum).
Catalogue Number492030
Brand Family Calbiochem®
Synonyms4H-8-Bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one
References
ReferencesFleming, I., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 1123.
Olesen, S.P., et al. 1998. Br. J. Pharmacol. 123, 299.
Product Information
CAS number204326-43-2
ATP CompetitiveN
FormWhite to off-white solid
Hill FormulaC₉H₅BrN₂O₃
Chemical formulaC₉H₅BrN₂O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetbasal soluble guanylyl cyclase
Primary Target IC<sub>50</sub>30 nM for basal and 200 nM for NO-stimulated enzyme activity; 17 nM for S-nitrosoglutathione-enhanced soluble guanylyl cyclase activity in homogenates of mouse cerebellum
Purity≥98% by NMR
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage. DMSO stock solutions are stable for up to 1 month at -20°C and for ~8 h at 4°C. Avoid freeze/thaw cycles of solutions.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
492030-5MG 04055977273557

Documentation

NS 2028 - CAS 204326-43-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

NS 2028 - CAS 204326-43-2 - Calbiochem Certificates of Analysis

TitleLot Number
492030

References

Reference overview
Fleming, I., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 1123.
Olesen, S.P., et al. 1998. Br. J. Pharmacol. 123, 299.

Brochure

Title
Pathways and Biomarkers of Oxidative Stress
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-April-2008 RFH
Synonyms4H-8-Bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one
DescriptionPotent, specific, and irreversible inhibitor of soluble guanylyl cyclase (IC50 = 30 nM for basal and 200 nM for NO-stimulated enzyme activity; IC50 = 17 nM for S-nitrosoglutathione-enhanced soluble guanylyl cyclase activity in homogenates of mouse cerebellum).
FormWhite to off-white solid
CAS number204326-43-2
Chemical formulaC₉H₅BrN₂O₃
Structure formulaStructure formula
Purity≥98% by NMR
SolubilityDMSO (5 mg/ml), Ethanol (5 mg/ml), or CHCl₃ (1 mg/ml)
Storage Protect from moisture
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage. DMSO stock solutions are stable for up to 1 month at -20°C and for ~8 h at 4°C. Avoid freeze/thaw cycles of solutions.
Toxicity Standard Handling
ReferencesFleming, I., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 1123.
Olesen, S.P., et al. 1998. Br. J. Pharmacol. 123, 299.