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492000 NOX Inhibitor III, VAS2870 - CAS 722456-31-7 - Calbiochem

The NOX Inhibitor III, VAS2870, also referenced under CAS 722456-31-7, controls the biological activity of NOX.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 7-(1,3-Benzoxazol-2-ylsulfanyl)-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine, 1,3-Benzoxazol-2-yl-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide, NADPH Oxidase Inhibitor III, VAS2870

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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
722456-31-7C₁₈H₁₂N₆OS
Description
OverviewA cell-permeable thiotriazolopyrimidine compound that acts as an effective NADPH oxidase (NOX) inhibitor (IC50 = 10.6 µM against NOX activity in human neutrophil lysates) and is widely used for studying NOX-dependent cellular ROS formations in various cultures, including oxLDL-treated HUVEC (complete inhibition at 5 µM), PDGF-induced primary rat VSMC (vascular smooth muscle cells; complete inhibition at 10 µM), as well as aortic sections from spontaneously hypertensive rats (72% inhibition at 10 µM) ex vivo.
Catalogue Number492000
Brand Family Calbiochem®
Synonyms7-(1,3-Benzoxazol-2-ylsulfanyl)-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine, 1,3-Benzoxazol-2-yl-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide, NADPH Oxidase Inhibitor III, VAS2870
References
ReferencesWind, S., et al. 2010. Hypertension 56, 490.
Lange, S., et al. 2009. Cardiovasc. Res. 81, 159.
Stielow, C., et al. 2006. Biochem. Biophys. Res. Commun. 344, 200.
ten Freyhaus, H., et al. 2006. Cardiovasc. Res. 71, 331.
Product Information
CAS number722456-31-7
FormTan solid
Hill FormulaC₁₈H₁₂N₆OS
Chemical formulaC₁₈H₁₂N₆OS
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
492000 0

Documentation

NOX Inhibitor III, VAS2870 - CAS 722456-31-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

NOX Inhibitor III, VAS2870 - CAS 722456-31-7 - Calbiochem Certificates of Analysis

TitleLot Number
492000

References

Reference overview
Wind, S., et al. 2010. Hypertension 56, 490.
Lange, S., et al. 2009. Cardiovasc. Res. 81, 159.
Stielow, C., et al. 2006. Biochem. Biophys. Res. Commun. 344, 200.
ten Freyhaus, H., et al. 2006. Cardiovasc. Res. 71, 331.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-April-2012 JSW
Synonyms7-(1,3-Benzoxazol-2-ylsulfanyl)-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine, 1,3-Benzoxazol-2-yl-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide, NADPH Oxidase Inhibitor III, VAS2870
DescriptionA cell-permeable thiotriazolopyrimidine compound that acts as an effective NADPH oxidase (NOX) inhibitor (IC50 = 10.6 µM against NOX activity in human neutrophil lysates) and is widely used for studying NOX-dependent cellular ROS formations in various cultures, including oxLDL-treated HUVEC (complete inhibition at 5 µM), PDGF-induced primary rat VSMC (vascular smooth muscle cells; complete inhibition at 10 µM), as well as aortic sections from spontaneously hypertensive rats (SHRs) (72% inhibition at 10 µM). Also shown to inhibit PDGF-BB-induced murine EB (embryonid body) vacularization (74% inhibition at 50 µM) and improve ACh-induced vasorelaxation of isolated rat aortic rings from both SHRs and non-hypertensive rats ex vivo (by 41.7 and 34.5%, respectively, at 10 µM).
FormTan solid
Intert gas (Yes/No) Packaged under inert gas
CAS number722456-31-7
Chemical formulaC₁₈H₁₂N₆OS
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (25 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesWind, S., et al. 2010. Hypertension 56, 490.
Lange, S., et al. 2009. Cardiovasc. Res. 81, 159.
Stielow, C., et al. 2006. Biochem. Biophys. Res. Commun. 344, 200.
ten Freyhaus, H., et al. 2006. Cardiovasc. Res. 71, 331.