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475886 NG-Monomethyl-L-arginine, Monoacetate Salt - CAS 53308-83-1 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Nω-Me-L-Arg, NG-Me-L-Arg, AcOH, L-NMMA

Primary Target: eNOS
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
53308-83-1C₇H₁₆N₄O₂ · CH₃CO₂H
Description
Overview

This product has been discontinued.



Cell permeable. L-Arginine analog that acts as a competitive inhibitor of all three isoforms of nitric oxide synthase (Ki = 700 nM for eNOS; Ki = 3.9 µM for iNOS; Ki = 650 nM for nNOS). Inhibits histamine- and acetylcholine-induced relaxation (Ki = 9.5 µM) of intact norepinephrine-constricted guinea pig pulmonary artery.
Catalogue Number475886
Brand Family Calbiochem®
SynonymsNω-Me-L-Arg, NG-Me-L-Arg, AcOH, L-NMMA
References
ReferencesReif, D.W., and McCreedy, S.A. 1995. Arch. Biochem. Biophys. 320, 170.
O’Kane, K.P., et al. 1994. Br. J. Clin. Pharmacol. 38, 311.
Kubes, P., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4651.
Mehta, J.L., et al. 1990. Biochem. Biophys. Res. Commun. 173, 438.
Thomas, G., et al. 1989. Biochem. Biophys. Res. Commun. 158, 177.
Sakuma, I., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 8664.
Hibbs, J.B., et al. 1987. Science 237, 473.
Palmer, R.M.J., et al. 1987. Nature 327, 524.
Product Information
CAS number53308-83-1
ATP CompetitiveN
FormWhite solid
Hill FormulaC₇H₁₆N₄O₂ · CH₃CO₂H
Chemical formulaC₇H₁₆N₄O₂ · CH₃CO₂H
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargeteNOS
Primary Target K<sub>i</sub>700 nM for eNOS; 3.9 µM for iNOS; 650 nM for nNOS
Purity≥99% by TLC; ≥99% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +15°C to +30°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 4 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
475886 0

Documentation

NG-Monomethyl-L-arginine, Monoacetate Salt - CAS 53308-83-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

NG-Monomethyl-L-arginine, Monoacetate Salt - CAS 53308-83-1 - Calbiochem Certificates of Analysis

TitleLot Number
475886

References

Reference overview
Reif, D.W., and McCreedy, S.A. 1995. Arch. Biochem. Biophys. 320, 170.
O’Kane, K.P., et al. 1994. Br. J. Clin. Pharmacol. 38, 311.
Kubes, P., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4651.
Mehta, J.L., et al. 1990. Biochem. Biophys. Res. Commun. 173, 438.
Thomas, G., et al. 1989. Biochem. Biophys. Res. Commun. 158, 177.
Sakuma, I., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 8664.
Hibbs, J.B., et al. 1987. Science 237, 473.
Palmer, R.M.J., et al. 1987. Nature 327, 524.

Brochure

Title
Pathways and Biomarkers of Oxidative Stress

Citations

Title
  • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision11-August-2008 RFH
    SynonymsNω-Me-L-Arg, NG-Me-L-Arg, AcOH, L-NMMA
    DescriptionL-Arginine analog that acts as a cell-permeable, competitive inhibitor of all three isoforms of nitric oxide synthase (NOS) (Ki = 650 nM for nNOS; Ki = 700 nM for eNOS; Ki = 3.9 µM for iNOS). Inhibits histamine- and acetylcholine-induced relaxation (Ki = 9.5 µM) of intact norepinephrine-constricted guinea pig pulmonary artery.
    FormWhite solid
    Intert gas (Yes/No) Packaged under inert gas
    CAS number53308-83-1
    Chemical formulaC₇H₁₆N₄O₂ · CH₃CO₂H
    Structure formulaStructure formula
    Purity≥99% by TLC; ≥99% by HPLC
    SolubilityH₂O (50 mg/ml) or Methanol
    Storage +15°C to +30°C
    Hygroscopic
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 4 months at -20°C.
    Toxicity Standard Handling
    ReferencesReif, D.W., and McCreedy, S.A. 1995. Arch. Biochem. Biophys. 320, 170.
    O’Kane, K.P., et al. 1994. Br. J. Clin. Pharmacol. 38, 311.
    Kubes, P., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4651.
    Mehta, J.L., et al. 1990. Biochem. Biophys. Res. Commun. 173, 438.
    Thomas, G., et al. 1989. Biochem. Biophys. Res. Commun. 158, 177.
    Sakuma, I., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 8664.
    Hibbs, J.B., et al. 1987. Science 237, 473.
    Palmer, R.M.J., et al. 1987. Nature 327, 524.
    Citation
  • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
    		•