Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

480025 NEMO-Binding Domain Binding Peptide, Cell-Permeable - Calbiochem

NEMO-Binding Domain Binding Peptide, Cell-Permeable, is an Antennapedia-NBD (wild type) fusion peptide that blocks the interaction of NEMO with the IKK (IκB)-kinase complex.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: DRQIKIWFQNRRMKWKKTALDWSWLQTE, NBD-Binding Peptide, Cell Permeable

Primary Target: cytokine-induced NF-κB activation and NF-κB-dependent gene expression
View Products on Sigmaaldrich.com
480025
  
Purchase on Sigma-Aldrich

Overview

Key Spec Table

Empirical Formula
C₁₇₀H₂₅₉N₄₉O₄₂S
Description
Overview

This product has been discontinued.



A cell-permeable Antennapedia-NBD (wild type) fusion peptide that exhibits anti-inflammatory properties. Acts by inhibiting cytokine-induced NF-κB activation and NF-κB-dependent gene expression. Suggested to block the interaction of NEMO with the IKK (IκB)-kinase complex and thereby prevents NF-κB activation. Does not affect the TNF-α-induced phosphorylation of c-Jun and DNA binding of the transcription factor Oct-1.
Catalogue Number480025
Brand Family Calbiochem®
SynonymsDRQIKIWFQNRRMKWKKTALDWSWLQTE, NBD-Binding Peptide, Cell Permeable
References
ReferencesJimi, E., et al. 2004. Nat. Med., 10, 617.
Siegmund, D., et al. 2001. J. Biol. Chem. 276, 43708.
May, M.J., et al. 2000. Science 289, 1550.
Li, Q., et al. 1999. Science 284, 321.
Product Information
ATP CompetitiveN
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₁₇₀H₂₅₉N₄₉O₄₂S
Chemical formulaC₁₇₀H₂₅₉N₄₉O₄₂S
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
ApplicationNEMO-Binding Domain Binding Peptide, Cell-Permeable, is an Antennapedia-NBD (wild type) fusion peptide that blocks the interaction of NEMO with the IKK (IκB)-kinase complex.
Biological Information
Primary Targetcytokine-induced NF-κB activation and NF-κB-dependent gene expression
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceH-Asp-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Thr-Ala-Leu-Asp-Trp-Ser-Trp-Leu-Gln-Thr-Glu-OH
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
480025 0