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487925 NBQX

487925
  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
118876-58-7C₁₂H₈N₄O₆S
Description
Overview

This product has been discontinued.





Potent, competitive, and selective AMPA receptor antagonist that is effective at nanomolar concentrations (Kd = 47 nM). Acts as a neuroprotectant.
Catalogue Number487925
Brand Family Calbiochem®
SynonymsFG 9202, 6-Nitro-7-sulphamoylbenzo[f]quinoxaline-2,3-dione, 2,3-Dihydroxy-6-nitro-7-sulphamoylbenzo[f]-quinoxaline
References
ReferencesDev, K.K., et al. 1996. J. Neurochem. 67, 2609.
Brasko, J., et al. 1995. Brain Res. 699, 133.
Yu, W., and Miller, R.F. 1995. Brain Res. 692, 190.
Lees, G.J., and Leong, W. 1994. NeuroReport 5, 2149.
Namba, T., et al. 1994. Brain. Res. 638, 36.
Gill, R., et al. 1992. Brain Res. 580, 35.
Product Information
CAS number118876-58-7
ATP CompetitiveN
DeclarationSold under license from Novo Nordisk.
FormYellow solid
Hill FormulaC₁₂H₈N₄O₆S
Chemical formulaC₁₂H₈N₄O₆S
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetAMPA receptor antagonist
Primary Target IC<sub>50</sub>Kd = 47 nM against AMPA receptor
Purity≥98% by TLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
487925 0

Documentation

NBQX SDS

Title

Safety Data Sheet (SDS) 

NBQX Certificates of Analysis

TitleLot Number
487925

References

Reference overview
Dev, K.K., et al. 1996. J. Neurochem. 67, 2609.
Brasko, J., et al. 1995. Brain Res. 699, 133.
Yu, W., and Miller, R.F. 1995. Brain Res. 692, 190.
Lees, G.J., and Leong, W. 1994. NeuroReport 5, 2149.
Namba, T., et al. 1994. Brain. Res. 638, 36.
Gill, R., et al. 1992. Brain Res. 580, 35.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-August-2008 RFH
SynonymsFG 9202, 6-Nitro-7-sulphamoylbenzo[f]quinoxaline-2,3-dione, 2,3-Dihydroxy-6-nitro-7-sulphamoylbenzo[f]-quinoxaline
DescriptionPotent, competitive and selective AMPA receptor antagonist which is effective at nanomolar concentrations. Acts as a neuroprotectant.
FormYellow solid
CAS number118876-58-7
Chemical formulaC₁₂H₈N₄O₆S
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityDMSO or methanol
Storage +15°C to +30°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
Toxicity Irritant
ReferencesDev, K.K., et al. 1996. J. Neurochem. 67, 2609.
Brasko, J., et al. 1995. Brain Res. 699, 133.
Yu, W., and Miller, R.F. 1995. Brain Res. 692, 190.
Lees, G.J., and Leong, W. 1994. NeuroReport 5, 2149.
Namba, T., et al. 1994. Brain. Res. 638, 36.
Gill, R., et al. 1992. Brain Res. 580, 35.