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399275 Nω-Hydroxy-nor-L-arginine, Diacetate Salt - CAS 189302-40-7 - Calbiochem

Nω-Hydroxy-nor-L-arginine, Diacetate Salt, CAS 189302-40-7, is a potent, selective, competitive, and high affinity inhibitor of arginase (IC50 = 2 µM for rat liver and 50 µM for mouse macrophages).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: L-2-Amino-(4-(2ʹ-hydroxyguanidino)butyric Acid, 2CH₃CO₂H, nor-NOHA, 2CH₃CO₂H

Primary Target: arginase from rat liver
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Overview

Key Spec Table

CAS #Empirical Formula
189302-40-7C₅H₁₂N₄O₃ · 2CH₃CO₂H

Products

Catalogue NumberPackaging Qty/Pack
399275-1MG Plastic ampoule 1 mg
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399275-5MG Plastic ampoule 5 mg
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Description
OverviewA potent, selective, competitive, and high affinity inhibitor of arginase. Shown to inhibit arginase from rat liver (IC50 = 2 µM) and mouse macrophages (IC50 = 50 µM). Shown to specifically interact with the manganese-cluster of the enzyme active site. Does not function as a substrate or as an inhibitor for NOS. Hence, nor-NOHA may be a useful tool to study the interplays between arginase and NOS.
Catalogue Number399275
Brand Family Calbiochem®
SynonymsL-2-Amino-(4-(2ʹ-hydroxyguanidino)butyric Acid, 2CH₃CO₂H, nor-NOHA, 2CH₃CO₂H
References
ReferencesGobert, A.P., et al. 2000. Infect. Immun. 68, 4653.
Meurs, H., et al. 2000. Br. J. Pharmacol. 130, 1793.
Moali, C., et al. 2000. Biochemistry 39, 8208.
Tenu, J.P. et al. 1999. Nitric Oxide 3, 427.
Moali, C., et al. 1998. Biochemistry 37, 10453.
Custot, J., et al. 1997. J. Am. Chem. Soc. 119, 4086.
Product Information
CAS number189302-40-7
FormOff-white solid
Hill FormulaC₅H₁₂N₄O₃ · 2CH₃CO₂H
Chemical formulaC₅H₁₂N₄O₃ · 2CH₃CO₂H
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationNω-Hydroxy-nor-L-arginine, Diacetate Salt, CAS 189302-40-7, is a potent, selective, competitive, and high affinity inhibitor of arginase (IC50 = 2 µM for rat liver and 50 µM for mouse macrophages).
Biological Information
Primary Targetarginase from rat liver
Primary Target IC<sub>50</sub>2 µM
Secondary targetmouse macrophages (IC₅₀ = 50 µM)
Purity≥97% by TLC
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
399275-1MG 04055977212563
399275-5MG 07790788049881