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47589 Mitomycin C, Streptomyces caespitosus - CAS 50-07-7 - Calbiochem

Antibiotic and carcinostatic agent. Inhibits DNA synthesis by cross-linking DNA at guanine and adenine residues; disrupts base pairing.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Mitocin C, MMC

47589
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
50-07-7C₁₅H₁₈N₄O₅
Description
Overview

This product has been discontinued.



Antibiotic and carcinostatic agent. Inhibits DNA synthesis by cross-linking DNA at guanine and adenine residues; disrupts base pairing. Forms covalent adducts into deoxyguanine and guanine under acidic conditions. Induces apoptosis in gastric cancer cells. Blocks the cell cycle at the G2 phase.
Catalogue Number47589
Brand Family Calbiochem®
SynonymsMitocin C, MMC
References
ReferencesKruyt, F.A., et al. 1996. Blood 89, 938.
Schwartz, G.K., et al. 1995. J. Natl. Cancer Inst. 87, 1394.
Folnan, R.S. 1993. Oncology 50 (Suppl. 1), 24.
Kawasaki, S., et al. 1992. Jpn. J. Cancer Res. 83, 899.
Malkinson, A.M., et al. 1992. Cancer Res. 52, 4752.
McEvoy, J.L., et al. 1992. J. Bacteriol. 174, 5471.
Tomasz, M., et al. 1987. Science 235, 1204.
Product Information
CAS number50-07-7
FormBlue-violet solid
FormulationProvided as 2 mg antibiotic and 48 mg NaCl.
Hill FormulaC₁₅H₁₈N₄O₅
Chemical formulaC₁₅H₁₈N₄O₅
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSCN0700000
Safety Information
R PhraseR: 28

Very toxic if swallowed.
S PhraseS: 36/37-45-28

Wear suitable protective clothing and gloves.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Highly Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C) for short-term storage and in a freezer (-20°C) for longer term. Stock solutions are stable for up to 2 weeks at 4°C and up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
47589 0

Documentation

Mitomycin C, Streptomyces caespitosus - CAS 50-07-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Mitomycin C, Streptomyces caespitosus - CAS 50-07-7 - Calbiochem Certificates of Analysis

TitleLot Number
47589

References

Reference overview
Kruyt, F.A., et al. 1996. Blood 89, 938.
Schwartz, G.K., et al. 1995. J. Natl. Cancer Inst. 87, 1394.
Folnan, R.S. 1993. Oncology 50 (Suppl. 1), 24.
Kawasaki, S., et al. 1992. Jpn. J. Cancer Res. 83, 899.
Malkinson, A.M., et al. 1992. Cancer Res. 52, 4752.
McEvoy, J.L., et al. 1992. J. Bacteriol. 174, 5471.
Tomasz, M., et al. 1987. Science 235, 1204.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-May-2008 RFH
SynonymsMitocin C, MMC
DescriptionAntibiotic and carcinostatic agent. Inhibits DNA synthesis by cross-linking DNA at guanine and adenine residues, disrupting base pairing. Induces apoptosis in gastic cancer cells. Blocks the cell cycle at the G2 phase.
FormBlue-violet solid
FormulationProvided as 2 mg antibiotic and 48 mg NaCl.
CAS number50-07-7
RTECSCN0700000
Chemical formulaC₁₅H₁₈N₄O₅
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityH₂O (1 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C) for short-term storage and in a freezer (-20°C) for longer term. Stock solutions are stable for up to 2 weeks at 4°C and up to 3 months at -20°C.
Toxicity Highly Toxic & Carcinogenic / Teratogenic
Merck USA index14, 6215
ReferencesKruyt, F.A., et al. 1996. Blood 89, 938.
Schwartz, G.K., et al. 1995. J. Natl. Cancer Inst. 87, 1394.
Folnan, R.S. 1993. Oncology 50 (Suppl. 1), 24.
Kawasaki, S., et al. 1992. Jpn. J. Cancer Res. 83, 899.
Malkinson, A.M., et al. 1992. Cancer Res. 52, 4752.
McEvoy, J.L., et al. 1992. J. Bacteriol. 174, 5471.
Tomasz, M., et al. 1987. Science 235, 1204.