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475876 Mitochondrial Permeability Transition Pore Reagents Set

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
475876
  
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Overview

Replacement Information
Description
Overview

This product has been discontinued.





Contains 1 g of Adenosine 5′-Diphosphate, Potassium Salt (Cat. No. 117105), 500 µg of Bongkrekic Acid, Triammonium Salt (Cat. No. 203671), 5 mg of Carboxyatractyloside, Atractylis gummifera (Cat. No. 216200), and 100 mg of Cyclosporin A, Tolypocladium inflatum (Cat. No. 239835). Supplied with a data sheet.
Catalogue Number475876
Brand Family Calbiochem®
References
Product Information
Hygroscopic Hygroscopic
Applications
Biological Information
Primary Targetcytosolic side specific mitochondrial ADP/ATP
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 23/24/25-40

Toxic by inhalation, in contact with skin and if swallowed.
Limited evidence of a carcinogenic effect.
S PhraseS: 22-24/25-36/37/39-45

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Multiple Toxicity Values, refer to MSDS
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
475876 0

Documentation

Mitochondrial Permeability Transition Pore Reagents Set Certificates of Analysis

TitleLot Number
475876
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision10-Febuary-2009 RFH
DescriptionThe mitochondiral permeability transition pore (PTP) is a proteinaceous aqueous pore of about 3 nm diameter that allows compounds of less than 1500 daltons to pass through. High levels of cytosolic Ca2+ and excessive concentrations of reactive oxygen species are known to contribute to the opening of the PTP, which depolarizes the mitochondria. The opening of PTP can be blocked by a decrease of pH, increase of ADP and Mg2+ concentrations. The PTP participates in the regulation of matrix Ca2+ levels, pH, and the volume. The PTP consists of an adenine nucleotide translocator (ANT) on the inner mitochondrial membrane and a voltage-dependent anion channel (VDAC) on the outer mitochondrial membrane. Hence, the PTP appears to be mainly localized in contact sites between the two membranes. The ANT is a specific antiporter that accounts for the exchange of ATP and ADP on inner membrane. VDAC, on the other hand, serves as the primary permeability pathway for metabolite flux between cytoplasmic and mitochondrial compartments. In the low-conductance state, the opening of PTP is pH dependent, which permits the diffusion of only small ions and then closes spontaneously. However, in the high-conductance state, the channel is stabilized in an open position and allows water and bigger molecules to enter the protein rich matrix. The mechanism of PTP formation and its biological significance have important implications in cellular bioenergetics, Ca2+ signaling, and apoptosis.

Calbiochem® brand offers a convenient Set containing 4 Mitochondrial Permeability Transition Pore Reagents with different specificities.
Intert gas (Yes/No) Packaged under inert gas
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Toxicity Multiple Toxicity Values, refer to MSDS