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475840 Milrinone - CAS 78415-72-2 - Calbiochem

A cell-permeable, selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC₅₀ = 300 nM).

Milrinone - CAS 78415-72-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1,6-Dihydro-2-methyl-6-oxo-(3,4ʹ-bipyridine)-5-carbonitrile

Primary Target: PDE 3
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
78415-72-2C₁₂H₉N₃O
Description
OverviewA cell-permeable, selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC50 = 300 nM). Has positive chronotropic, inotropic, and vasodilatory effects on the heart.
Catalogue Number475840
Brand Family Calbiochem®
Synonyms1,6-Dihydro-2-methyl-6-oxo-(3,4ʹ-bipyridine)-5-carbonitrile
References
ReferencesBailey, J.M., et al. 1994. Anesthesiology 81, 616.
Wilhelm, D., et al. 1992. J. Cardiovasc. Pharmacol. 20, 705.
Lindgren, S.H., et al. 1990. Acta. Phys. Scand. 140, 209.
Harrison, S.A., et al. 1986. Mol. Pharmacol. 29, 506.
Product Information
CAS number78415-72-2
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₂H₉N₃O
Chemical formulaC₁₂H₉N₃O
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPDE 3
Primary Target IC<sub>50</sub>300 nM against PDE III
Purity≥99% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSDW1762000
Safety Information
R PhraseR: 23/24/25

Toxic by inhalation, in contact with skin and if swallowed.
S PhraseS: 36/37/39-45

Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
475840 0

Documentation

Milrinone - CAS 78415-72-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Milrinone - CAS 78415-72-2 - Calbiochem Certificates of Analysis

TitleLot Number
475840

References

Reference overview
Bailey, J.M., et al. 1994. Anesthesiology 81, 616.
Wilhelm, D., et al. 1992. J. Cardiovasc. Pharmacol. 20, 705.
Lindgren, S.H., et al. 1990. Acta. Phys. Scand. 140, 209.
Harrison, S.A., et al. 1986. Mol. Pharmacol. 29, 506.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-July-2014 JSW
Synonyms1,6-Dihydro-2-methyl-6-oxo-(3,4ʹ-bipyridine)-5-carbonitrile
DescriptionA cell-permeable, selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III, IC50 = 300 nM). Has positive chronotropic, ionotropic, and vasodilatory effects on the heart.
FormWhite solid
CAS number78415-72-2
RTECSDW1762000
Chemical formulaC₁₂H₉N₃O
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (20 mg/ml) or Ethanol (3 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Toxicity Toxic
Merck USA index14, 6197
ReferencesBailey, J.M., et al. 1994. Anesthesiology 81, 616.
Wilhelm, D., et al. 1992. J. Cardiovasc. Pharmacol. 20, 705.
Lindgren, S.H., et al. 1990. Acta. Phys. Scand. 140, 209.
Harrison, S.A., et al. 1986. Mol. Pharmacol. 29, 506.