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475840 Milrinone - CAS 78415-72-2 - Calbiochem

A cell-permeable, selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC₅₀ = 300 nM).

Milrinone - CAS 78415-72-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1,6-Dihydro-2-methyl-6-oxo-(3,4ʹ-bipyridine)-5-carbonitrile

Primary Target: PDE 3
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Overview

Key Spec Table

CAS #Empirical Formula
78415-72-2C₁₂H₉N₃O
Description
OverviewA cell-permeable, selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC50 = 300 nM). Has positive chronotropic, inotropic, and vasodilatory effects on the heart.
Catalogue Number475840
Brand Family Calbiochem®
Synonyms1,6-Dihydro-2-methyl-6-oxo-(3,4ʹ-bipyridine)-5-carbonitrile
References
ReferencesBailey, J.M., et al. 1994. Anesthesiology 81, 616.
Wilhelm, D., et al. 1992. J. Cardiovasc. Pharmacol. 20, 705.
Lindgren, S.H., et al. 1990. Acta. Phys. Scand. 140, 209.
Harrison, S.A., et al. 1986. Mol. Pharmacol. 29, 506.
Product Information
CAS number78415-72-2
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₂H₉N₃O
Chemical formulaC₁₂H₉N₃O
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetPDE 3
Primary Target IC<sub>50</sub>300 nM against PDE III
Purity≥99% by HPLC
Physicochemical Information
Cell permeableY
Safety Information according to GHS
RTECSDW1762000
Safety Information
R PhraseR: 23/24/25

Toxic by inhalation, in contact with skin and if swallowed.
S PhraseS: 36/37/39-45

Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Global Trade Item Number
Catalogue Number GTIN
475840 0