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444247 MMP Inhibitor II - CAS 203915-59-7 - Calbiochem

The MMP Inhibitor II, also referenced under CAS 203915-59-7, controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-Hydroxy-1,3-di-(4-methoxybenzenesulphonyl)-5,5-dimethyl-[1,3]-piperazine-2-carboxamide

Primary Target: MMP-1
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
203915-59-7C₂₁H₂₇N₃O₈S₂
Description
OverviewA potent, reversible, broad-range inhibitor of matrix metalloproteinases. Inhibits MMP-1 (IC50 = 24 nM), MMP-3 (IC50 = 18.4 nM), MMP-7 (IC50 = 30 nM), and MMP-9 (IC50 = 2.7 nM).
Catalogue Number444247
Brand Family Calbiochem®
SynonymsN-Hydroxy-1,3-di-(4-methoxybenzenesulphonyl)-5,5-dimethyl-[1,3]-piperazine-2-carboxamide
References
ReferencesPikul, S., et al. 1998. J. Med. Chem. 41, 3568.
Product Information
CAS number203915-59-7
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₂₁H₂₇N₃O₈S₂
Chemical formulaC₂₁H₂₇N₃O₈S₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMMP-1
Primary Target IC<sub>50</sub>24 nM, 18.4 nM, 30 nM, 2.7 nM, against MMP-1, MMP-3, MMp-7, and MMP-9, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
444247 0

Documentation

MMP Inhibitor II - CAS 203915-59-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

MMP Inhibitor II - CAS 203915-59-7 - Calbiochem Certificates of Analysis

TitleLot Number
444247

References

Reference overview
Pikul, S., et al. 1998. J. Med. Chem. 41, 3568.

Citations

Title
  • Haili Su, et al. (2005) Noninvasive targeted imaging of matrix metalloproteinase activation in a murine model of postinfarction remodeling. Circulation 112, 3157-3167.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision03-April-2008 RFH
    SynonymsN-Hydroxy-1,3-di-(4-methoxybenzenesulphonyl)-5,5-dimethyl-[1,3]-piperazine-2-carboxamide
    DescriptionA potent, reversible, broad range inhibitor of matrix metalloproteinases. Inhibits MMP-1 (IC50 = 24 nM), MMP-3 (IC50 = 18.4 nM), MMP-7 (IC50 = 30 nM), and MMP-9 (IC50 = 2.7 nM).
    FormOff-white solid
    Intert gas (Yes/No) Packaged under inert gas
    CAS number203915-59-7
    Chemical formulaC₂₁H₂₇N₃O₈S₂
    Structure formulaStructure formula
    Purity≥95% by HPLC
    SolubilityDMSO (100 mg/ml). Requires vigorous vortexing for 60 seconds to completely solubilize the product.
    Storage -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    Toxicity Standard Handling
    ReferencesPikul, S., et al. 1998. J. Med. Chem. 41, 3568.
    Citation
  • Haili Su, et al. (2005) Noninvasive targeted imaging of matrix metalloproteinase activation in a murine model of postinfarction remodeling. Circulation 112, 3157-3167.
    		•