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444294 MMP-2 Inhibitor IV - Calbiochem

Overview

Key Spec Table

Empirical Formula
C₁₃H₁₄ClNO₈P₂S

Products

Catalogue NumberPackaging Qty/Pack
444294-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable, bisphosphonate derivative that displays nanomolar activity against MMP-2 (IC50 = 37 nM), with good selectivity over MMP-8 (320 nM), MMP-9 (> 1 µM), and MMP-14 (> 1 µM). It is shown to inhibit osteoclast activity in a macrophage cell line, J774 (IC50 = 1.7 µM), which is more potent compared with other bisphosphonates such as Alendronate (Cat. No. 126855), (IC50 = 30 µM), and Zolendronate (7.8 µM), without observable cytotoxicity in HepG2 cells. At 25 µM, it abolishes the formation of actin rings, which are functional structures that are typical of resorbing osteoclasts, at activity levels comparable with those of zolendronic acid, inhibits bone resportion in vitro, and demonstrates cytotoxic properties in murine osteoclasts.
Catalogue Number444294
Brand Family Calbiochem®
SynonymsBone Resorption Inhibitor, (4'-chlorobiphenyl-4-ylsulfonamido)methylenediphosphonic acid
References
ReferencesRubino, M.T., et al. 2011. Chem. Med. Chem. 6, 1258.
Product Information
FormOff-white powder
Hill FormulaC₁₃H₁₄ClNO₈P₂S
Chemical formulaC₁₃H₁₄ClNO₈P₂S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥99% by HPLC
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
444294-10MG 04055977186109