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505770 LSD1 Inhibitor VI, Cpd 2d - Calbiochem

A cell-permeable inhibitor of lysine-specific demethylase-1 (LSD1, KDM1). Inhibits growth of AML cell lines at low micromolar concentrations (5 to 10 µM).

LSD1 Inhibitor VI, Cpd 2d - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1,15-bis{N5-[3,3-(diphenyl)propyl]-N1-biguanido}-4,12-diazapentadecane

Primary Target: LSD1
505770
  
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₄₇H₆₈N₁₂
Description
Overview

This product has been discontinued.



A cell-permeable polyamine derivative that acts as an inhibitor of lysine-specific demethylase-1 (LSD1, KDM1) and increases levels of mono- and di-methylated histone H3K4, H3K9 proteins in acute myeloid leukemia (AML) cancer cells in a dose-dependent manner. Shown to cause significant growth inhibition in different AML cell lines (HL-60, KG1a, HNT-34, and ML-1 cells) at low micromolar concentrations (5 to 10 µM) over a period of 96 hours. Induces re-expression of cancer suppressing E-caherin gene and CDH-1 mRNA in tumor cells (˜10 µM). Also, displays anti-trypanosomal properties and inhibits trypanothione reductase activity (IC50 = 950 nM) in Trypanosoma brucei brucei.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number505770
Brand Family Calbiochem®
Synonyms1,15-bis{N5-[3,3-(diphenyl)propyl]-N1-biguanido}-4,12-diazapentadecane
References
ReferencesMurray-Stewart, T., et al. 2013, Amino Acids 44, in press.
Bi, X. et al. 2006, Bioorg. Med. Chem. Lett. 16,3229.
Product Information
FormOff-white solid
Hill FormulaC₄₇H₆₈N₁₂
Chemical formulaC₄₇H₆₈N₁₂
Hygroscopic Hygroscopic
Quality LevelMQ100
Applications
Biological Information
Primary TargetLSD1
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
505770 0

Documentation

LSD1 Inhibitor VI, Cpd 2d - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Murray-Stewart, T., et al. 2013, Amino Acids 44, in press.
Bi, X. et al. 2006, Bioorg. Med. Chem. Lett. 16,3229.

Brochure

Title
NPI Flyer- Epigenetics and Nuclear Function Feature
New Products - Antibodies, Small Molecule, Inhibitors

Technical Info

Title
White Paper: Further considerations of antibody validation and usage.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-September-2014 JSW
Synonyms1,15-bis{N5-[3,3-(diphenyl)propyl]-N1-biguanido}-4,12-diazapentadecane
DescriptionA cell-permeable polyamine derivative that acts as an inhibitor of lysine-specific demethylase-1 (LSD1, KDM1) and increases levels of mono- and di-methylated histone H3K4, H3K9 proteins in acute myeloid leukemia (AML) cancer cells in a dose-dependent manner. Shown to cause significant growth inhibition in different AML cell lines (HL-60, KG1a, HNT-34, and ML-1 cells) at low micromolar concentrations (5 to 10 µM) over a period of 96 hours. Induces re-expression of cancer suppressing E-caherin gene and CDH-1 mRNA in tumor cells (˜10 µM). Also, displays anti-trypanosomal properties and inhibits trypanothione reductase activity (IC50 = 950 nM) in Trypanosoma brucei brucei.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₄₇H₆₈N₁₂
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesMurray-Stewart, T., et al. 2013, Amino Acids 44, in press.
Bi, X. et al. 2006, Bioorg. Med. Chem. Lett. 16,3229.