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489476 LSD1 Inhibitor - CAS 927019-63-4 - Calbiochem

The LSD1 Inhibitor, also referenced under CAS 927019-63-4, controls the biological activity of LSD1. This small molecule/inhibitor is primarily used for Cell Signaling applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: LSD Inhibitor I, BHC110 Inhibitor I, Histone Lysine Demethylase Inhibitor III, KDM1 Inhibitor I

489476
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
927019-63-4C₁₅H₄₀Cl₄N₈
Description
OverviewA bisguanidine polyamine analogue that exhibits noncompetitive and specific LSD1 inhibition, with 14.1% remaining LSD1 activity at 10 µM in vitro, and is shown to significantly increase methylation at the histone 3 lysine 4 chromatin mark (H3K4me1 and H3K4me2) dose-dependently from 0.25 µM to 10 µM, without affecting global H3K9me2 (which is not a LSD1 substrate) levels in HCT116 human colon carcinoma cells. This compound induces reexpression of several epigenetically silenced genes including SFRP1, SFRP4, SFRP5, and GATA5 more effectively when compared with siRNA treatment, particularly in the case of SFRP4 and SFRP5.
Catalogue Number489476
Brand Family Calbiochem®
SynonymsLSD Inhibitor I, BHC110 Inhibitor I, Histone Lysine Demethylase Inhibitor III, KDM1 Inhibitor I
References
ReferencesSharma, SK., et al. 2010 J. Med. Chem. 53, 5197.
Huang, Y., et al. 2007. Proc. Natl. Acad. Sci. 104, 8023.
Bi, X., et al. 2006. Bioorg. Med. Chem. Lett. 16, 3229.
Product Information
CAS number927019-63-4
FormPale yellow to yellow solid
Hill FormulaC₁₅H₄₀Cl₄N₈
Chemical formulaC₁₅H₄₀Cl₄N₈
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
489476 0

Documentation

LSD1 Inhibitor - CAS 927019-63-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

LSD1 Inhibitor - CAS 927019-63-4 - Calbiochem Certificates of Analysis

TitleLot Number
489476

References

Reference overview
Sharma, SK., et al. 2010 J. Med. Chem. 53, 5197.
Huang, Y., et al. 2007. Proc. Natl. Acad. Sci. 104, 8023.
Bi, X., et al. 2006. Bioorg. Med. Chem. Lett. 16, 3229.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-July-2011 RFH
SynonymsLSD Inhibitor I, BHC110 Inhibitor I, Histone Lysine Demethylase Inhibitor III, KDM1 Inhibitor I
DescriptionA bisguanidine polyamine analogue that exhibits noncompetitive and specific LSD1 inhibition, with 14.1% remaining LSD1 activity at 10 µM in vitro, and is shown to significantly increase methylation at the histone 3 lysine 4 chromatin mark (H3K4me1 and H3K4me2) dose-dependently from 0.25 µM to 10 µM, without affecting global H3K9me2 (which is not a LSD1 substrate) levels in HCT116 human colon carcinoma cells. This compound induces reexpression of several epigenetically silenced genes including SFRP1, SFRP4, SFRP5, and GATA5 more effectively when compared with siRNA treatment, particularly in the case of SFRP4 and SFRP5.
FormPale yellow to yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number927019-63-4
Chemical formulaC₁₅H₄₀Cl₄N₈
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityH₂O (50 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSharma, SK., et al. 2010 J. Med. Chem. 53, 5197.
Huang, Y., et al. 2007. Proc. Natl. Acad. Sci. 104, 8023.
Bi, X., et al. 2006. Bioorg. Med. Chem. Lett. 16, 3229.