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108378 L-Tyrosine

EMPROVE® EXPERT Ph Eur,ChP,JP,USP

L-Tyrosine MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-Hydroxyphenylalanine, Tyr

CAS #: 60-18-4 EC Number: 200-460-4 Molar Mass: 181.19 g/mol Hill Formula: C₉H₁₁NO₃ Grade: Ph Eur,ChP,JP,USP
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Overview

Replacement Information

Key Spec Table

CAS #EC NumberHill FormulaMolar MassGrade Value
60-18-4200-460-4C₉H₁₁NO₃181.19 g/molPh Eur,ChP,JP,USP

Products

Catalogue NumberPackaging Qty/Pack
1083781000 Plastic bottle 1 kg
1083789010 Plastic drum 10 kg
Description
Catalogue Number108378
Synonyms4-Hydroxyphenylalanine, Tyr
References
Product Information
CAS number60-18-4
EC number200-460-4
GradePh Eur,ChP,JP,USP
Hill FormulaC₉H₁₁NO₃
Molar Mass181.19 g/mol
HS Code2922 50 39
Structure formula ImageStructure formula Image
Quality LevelMQ500
Applications
Biological Information
Physicochemical Information
Density1.46 g/cm3
Melting Point343 °C (decomposition)
pH value6.5 (0.1 g/l, H₂O)
Bulk density300 kg/m3
Solubility0.38 g/l
Dimensions
Materials Information
Toxicological Information
LD 50 oralLD50 Rat > 5110 mg/kg
Safety Information according to GHS
RTECSYP2275600
Storage class10 - 13 Other liquids and solids
WGKWGK 1 slightly hazardous to water
Disposal3
Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C.
Safety Information
Product Usage Statements
Storage and Shipping Information
StorageStore at +2°C to +30°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Assay (perchloric acid titration, calculated on dried substance)99.0 - 101.0 %
Identity (IR-spectrum)passes test
Identity (specific rotation)passes test
Identity (TLC)passes test
Identity (UV/VIS-Spectrum)passes test
Appearancewhite to almost white, crystalline powder or colorless crystals
Appearance of solution (25 g/l, Hydrochloric acid 2 mol/l)clear and not more intense in color than reference solution Y₇
Appearance of solution (50 g/l, hydrochloric acid 1 mol/l)clear and colorless
Transmittance of solution (50 g/l, hydrochloric acid 1 mol/l)≥ 95.0 %
Spec. rotation (α 20/D, 50 g/l, hydrochloric acid 1 mol/l, calc. on dried substance)-12.1 to -11.3
Spec. rotation (α 20/D, 50 g/l, hydrochloric acid 1 mol/l, previously dried substance)-12.5 to -10.5
Spec. rotation (α 25/D, 50 g/l, hydrochloric acid 1 mol/l, calc. on dried substance)-11.2 to -9.8
Acidity (0,2 g/l, CO2 free water)5.0 - 6.5
Chloride (Cl)≤ 200 ppm
Sulfate (SO₄)≤ 200 ppm
Heavy metals (as Pb)≤ 10 ppm
As (Arsenic)≤ 1 ppm
Fe (Iron)≤ 10 ppm
Other amino acids (TLC)≤ 0.4 %
Related Compounds, total (TLC)≤ 0.5 %
Related substances (TLC)passes test
Ninhydrin-positive substances (LC) (impurity A (570 nm))≤ 0.5 %
Ninhydrin-positive substances (LC) (any ninhydrin-positive impurity)≤ 0.2 %
Ninhydrin-positive substances (LC) (ammonium (570 nm))≤ 0.02 %
Ninhydrin-positive substances (LC) (total impurities)≤ 0.6 %
Residual solvents (ICH (Q3C))excluded by manufacturing process
Sulfated ash (600 °C)≤ 0.1 %
Loss on drying (105 °C; 3 h)≤ 0.2 %
Bacterial endotoxins≤ 20 I.U./g
Microbiological test (total aerobic microbial count (TAMC))≤ 10²
Microbiological test (total yeast and mould count (TYMC))≤ 10²
Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
Corresponds to Ph. Eur., ChP, JP, USP
Global Trade Item Number
Catalogue Number GTIN
1083781000 04022536906980
1083789010 04022536906997

Documentation

Material Qualification Dossier

TitleVersion
9.0

Quality Management Dossier (Open Access)

Title

Operational Excellence Dossier

Title

L-Tyrosine SDS

Title

Safety Data Sheet (SDS) 

L-Tyrosine Certificates of Analysis

Product Number PackagingSpecificationLot Number
1083781000 Plastic bottlePDF Specification Document
1083789010 Plastic drumPDF Specification Document

Certificates

Title