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505879 L-741,626 - CAS 81226-60-0 - Calbiochem

L-741,626 - CAS 81226-60-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Dopamine D₂ Receptor Antagonist, L-741,626, L-741626, L741626

Primary Target: D₂
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
81226-60-0C₂₀H₂₁ClN₂O
Description
Overview

This product has been discontinued.



Selective dopamine D2 receptor antagonist that is shown to reversibly block agonist-induced activation of GIRK currents. Reported to have a 15-fold selectivity for D2R over D3R in vitro. Inhibition of 3H-spirperone binding to cloned rat Dopamine receptors show the following Ki values: D2R (7.1 nM), D3R (155 nM), D4R (596 nM). Commonly used D2 inhibitor in addiction research.
Catalogue Number505879
Brand Family Calbiochem®
SynonymsDopamine D₂ Receptor Antagonist, L-741,626, L-741626, L741626
References
ReferencesGrundt, P. et al. 2007. Bioorg. Med. Chem. Lett. 17, 745.
Caine, S. B. et al. 2002. J. Neurosci. 22, 2977.
Pillai, G. et al. 1998. Neuropharmacol. 337, 983.
Product Information
CAS number81226-60-0
FormWhite solid
Hill FormulaC₂₀H₂₁ClN₂O
Chemical formulaC₂₀H₂₁ClN₂O
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetD₂
Primary Target K<sub>i</sub>7.1 nM
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
505879 0

Documentation

L-741,626 - CAS 81226-60-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Grundt, P. et al. 2007. Bioorg. Med. Chem. Lett. 17, 745.
Caine, S. B. et al. 2002. J. Neurosci. 22, 2977.
Pillai, G. et al. 1998. Neuropharmacol. 337, 983.

Brochure

Title
New Products Flyer- Feb 2014 - Vol 1
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-September-2013 JSW
SynonymsDopamine D₂ Receptor Antagonist, L-741,626, L-741626, L741626
DescriptionSelective dopamine D2 receptor antagonist that is shown to reversibly block agonist-induced activation of GIRK currents. Reported to have a 15-fold selectivity for D2R over D3R in vitro. Inhibition of 3H-spirperone binding to cloned rat Dopamine receptors show the following Ki values: D2R (7.1 nM), D3R (155 nM), D4R (596 nM). Commonly used D2 inhibitor in addiction research.
FormWhite solid
CAS number81226-60-0
Chemical formulaC₂₀H₂₁ClN₂O
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesGrundt, P. et al. 2007. Bioorg. Med. Chem. Lett. 17, 745.
Caine, S. B. et al. 2002. J. Neurosci. 22, 2977.
Pillai, G. et al. 1998. Neuropharmacol. 337, 983.