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422682 Kir1.1 Inhibitor, VU591 - Calbiochem

The Kir1.1 Inhibitor, VU591 controls the biological activity of Kir1.1. This small molecule/inhibitor is primarily used for Neuroscience applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Inward rectifier potassium channel Kir1.1 blocker, VU591

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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₆H₁₂N₆O₅
Description
Overview

This product has been discontinued.



A cell-permeable, benzoimidazole, renal outer medullary potassium channel (ROMK) blocker that selectively inhibits inward rectifier potassium channel, Kir1.1 (IC50 = 240 nM), in HEK-293 cells. At 10 µM, it displays no effect on Kir2.1, Kir2.3, Kir4.1, and Kir7.1, with 150-fold selectivity over Kir6.2. In addition, it exhibits a modest off-target effect on the GABAA receptor (IC50 = 6.2 µM) among a panel of cardiac and central nervous system ion channels and receptors.
Catalogue Number422682
Brand Family Calbiochem®
SynonymsInward rectifier potassium channel Kir1.1 blocker, VU591
References
ReferencesBhave, G., et al. 2011. Mol Pharmacol. 79, 42.
Product Information
FormLight gray solid
Hill FormulaC₁₆H₁₂N₆O₅
Chemical formulaC₁₆H₁₂N₆O₅
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Regulatory Review
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
422682 0

Documentation

Kir1.1 Inhibitor, VU591 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Kir1.1 Inhibitor, VU591 - Calbiochem Certificates of Analysis

TitleLot Number
422682

References

Reference overview
Bhave, G., et al. 2011. Mol Pharmacol. 79, 42.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-May-2012 JSW
SynonymsInward rectifier potassium channel Kir1.1 blocker, VU591
DescriptionA cell-permeable, benzoimidazole, renal outer medullary potassium channel (ROMK) blocker that selectively inhibits inward rectifier potassium channel, Kir1.1 (IC50 = 240 nM), in HEK-293 cells. At 10 µM, it displays no effect on Kir2.1, Kir2.3, Kir4.1, and Kir7.1, with 150-fold selectivity over Kir6.2. In addition, it exhibits a modest off-target effect on the GABAA receptor (IC50 = 6.2 µM) among a panel of cardiac and central nervous system ion channels and receptors.
FormLight gray solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₆H₁₂N₆O₅
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml; clear, dark brown solution)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Regulatory Review
ReferencesBhave, G., et al. 2011. Mol Pharmacol. 79, 42.