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420336 KB-R7943 - CAS 182004-65-5 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
182004-65-5C₁₆H₁₇N₃O₃S • MeSO₃H

Products

Catalogue NumberPackaging Qty/Pack
420336-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable isothiourea derivative that inhibits the influx/reverse mode of Na+/Ca2+ exchangers (NCX; IC50 = 4.3 µM, 4.7 µM, and 1.4 µM for NCX1,NCX2, and NCX3, respectively) and directly modulates Na+/Mg2+ exchange in a Ca2+-dependent manner. Reported to offer neuronal and cardioprotection. Also inhibits nicotinic acetylcholine receptors and NMDA receptor channels (IC50 < 10 µM).
Catalogue Number420336
Brand Family Calbiochem®
Synonyms2-(2-(4-(4-Nitrobenzyloxy)phenyl)ethyl)isothiourea, methane sulfonate, NMDA Antagonist III
References
ReferencesHobai, I.A., and O'Rourke, B. 2004. Expert Opin. Investig. Drugs 13, 653.
Uetani, T., et al. 2003. J. Biol. Chem. 278, 47491.
Iwamoto, T., et al. 2001. Mol. Pharmacol. 59, 524.
Pintado, A.J., et al. 2000. Br. J. Pharmacol. 130, 1893.
Sobolevsky, A.I., and Khodorov, B.I. 1999. Neuropharmacology 38, 1235.
Iwamoto, T., et al. 1996. J. Biol. Chem. 271, 22391.
Watano, T., et al. 1996. Br. J. Pharmacol. 119, 555.
Product Information
CAS number182004-65-5
ATP CompetitiveN
FormWhite crystalline solid
Hill FormulaC₁₆H₁₇N₃O₃S • MeSO₃H
Chemical formulaC₁₆H₁₇N₃O₃S • MeSO₃H
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetNa+/Ca2+ exchangers
Primary Target IC<sub>50</sub>4.3 µM, 4.7 µM, and 1.4 µM for NCX1,NCX2, and NCX3, respectively
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
420336-5MG 07790788050160