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407271 Integrin αMβ₂ Ligand - CAS 307525-40-2 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(o-Tolyl)-5-(3-phenyl-2-propenylidene)-2-thioxo-1,3-thiazolin-4-one, IMB-10, αMβ2 Agonist I, CD11b Agonist I, CD11b/CD18 Agonist I, CR3 Agonist I, Mac-1 Agonist I

Primary Target: Binds to and stabilizes integrin αM I domain active conformation
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
307525-40-2C₁₉H₁₅NOS₂
Description
Overview

This product has been discontinued.



A cell-permeable thioxothiazolidine compound that displays anti-inflammatory properties. Shown to increase cell adhesion and lowers leukemia cell migration in vitro and leukocyte recruitment in vivo and displays anti-inflammatory properties. Binds to and stabilizes integrin αM I domain active conformation and enhances the ligands' (pro-MMP-9 and fibrinogen) binding ability.
Catalogue Number407271
Brand Family Calbiochem®
Synonyms3-(o-Tolyl)-5-(3-phenyl-2-propenylidene)-2-thioxo-1,3-thiazolin-4-one, IMB-10, αMβ2 Agonist I, CD11b Agonist I, CD11b/CD18 Agonist I, CR3 Agonist I, Mac-1 Agonist I
References
ReferencesBjorklund, M., et al. 2006. Biochemistry 45, 2862.
Product Information
CAS number307525-40-2
ATP CompetitiveN
FormYellow solid
Hill FormulaC₁₉H₁₅NOS₂
Chemical formulaC₁₉H₁₅NOS₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetBinds to and stabilizes integrin αM I domain active conformation
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
407271 0

Documentation

Integrin αMβ₂ Ligand - CAS 307525-40-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Bjorklund, M., et al. 2006. Biochemistry 45, 2862.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-April-2011 RFH
Synonyms3-(o-Tolyl)-5-(3-phenyl-2-propenylidene)-2-thioxo-1,3-thiazolin-4-one, IMB-10, αMβ2 Agonist I, CD11b Agonist I, CD11b/CD18 Agonist I, CR3 Agonist I, Mac-1 Agonist I
DescriptionA cell-permeable thioxothiazolidine compound that displays anti-inflammatory properties. Shown to increase cell adhesion and lowers leukemia cell migration in vitro and leukocyte recruitment in vivo and displays anti-inflammatory properties. Binds to and stabilizes integrin αM I domain active conformation and enhances the ligands' (pro-MMP-9 and fibrinogen) binding ability.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number307525-40-2
Chemical formulaC₁₉H₁₅NOS₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (15 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBjorklund, M., et al. 2006. Biochemistry 45, 2862.