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401484 InSolution™ IKK-2 Inhibitor IV - Calbiochem

The InSolution™ IKK-2 Inhibitor IV controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

InSolution™ IKK-2 Inhibitor IV - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: IKK-2
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401484
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₂H₁₀FN₃O₂S

Products

Catalogue NumberPackaging Qty/Pack
401484-500UG Plastic ampoule 500 μg
Description
Catalogue Number401484
Brand Family Calbiochem®
References
ReferencesPodolin, P.L., et al. 2005. J. Pharmacol. Exp. Ther. 312, 373.
Karin, M., et al. 2004. Nat. Rev. Drug Discov. 3, 17.
Roshak, A.K., et al. 2002. Inflamm. Res. 51, S4.
Product Information
ATP CompetitiveY
FormClear pale yellow Liquid
FormulationA 10 mM (500 µg/179 µl) solution of IKK-2 Inhibitor IV (Cat. No. 401481) in DMSO.
Hill FormulaC₁₂H₁₀FN₃O₂S
Chemical formulaC₁₂H₁₀FN₃O₂S
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetIKK-2
Primary Target IC<sub>50</sub>18 nM
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
401484-500UG 04055977211993

Documentation

InSolution™ IKK-2 Inhibitor IV - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™ IKK-2 Inhibitor IV - Calbiochem Certificates of Analysis

TitleLot Number
401484

References

Reference overview
Podolin, P.L., et al. 2005. J. Pharmacol. Exp. Ther. 312, 373.
Karin, M., et al. 2004. Nat. Rev. Drug Discov. 3, 17.
Roshak, A.K., et al. 2002. Inflamm. Res. 51, S4.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-July-2008 RFH
DescriptionIKK-2 Inhibitor IV (Cat. No. 401481) supplied in DMSO. A cell-permeable and potent inhibitor of IKK-2 (IC50 = 18 nM) that exhibits selectivity over IKK-1, JNK, and p38 MAPK. Inhibits TNF-α production in human monocytes (IC50 in the range of 0.15-2.5 µM) and blocks IL-8 and IL-6 production by synovial fibroblasts (IC50 = 100 nM). Shown to reduce paw oedema in rat arthritis model (~100% inhibition at a dose of 30 mg/kg).
FormClear pale yellow Liquid
FormulationA 10 mM (500 µg/179 µl) solution of IKK-2 Inhibitor IV (Cat. No. 401481) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₂H₁₀FN₃O₂S
Structure formulaStructure formula
Purity≥95% by HPLC
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
Toxicity Irritant
ReferencesPodolin, P.L., et al. 2005. J. Pharmacol. Exp. Ther. 312, 373.
Karin, M., et al. 2004. Nat. Rev. Drug Discov. 3, 17.
Roshak, A.K., et al. 2002. Inflamm. Res. 51, S4.