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239765 InSolution™ Cycloheximide - CAS 66-81-9 - Calbiochem

InSolution™ Cycloheximide, CAS 66-81-9, is a 100 mg/ml, sterile-filtered solution of Cycloheximide (Cat. No. 239763) in DMSO. An antifungal antibiotic that inhibits protein synthesis in eukaryotes.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: hFKBP12
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
66-81-9C₁₅H₂₃NO₄
Description
Catalogue Number239765
Brand Family Calbiochem®
References
ReferencesChristner, C., et al. 1999. J. Med. Chem. 42, 3615.
Lu, Q. and Mellgreen,R.L. 1996. Arch. Biochem. Biophys. 334, 175.
Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
Waring, P. 1990. J. Biol. Chem. 265, 14476.
Obrig, T.G., et al. 1971. J. Biol. Chem. 246, 174.
Pestka, S. 1971. Annu. Rev. Microbiol. 25, 487.
Product Information
CAS number66-81-9
FormLiquid
FormulationA 100 mg/ml solution of Cycloheximide (Cat. No. 239763) in DMSO (sterile-filtered).
Hill FormulaC₁₅H₂₃NO₄
Chemical formulaC₁₅H₂₃NO₄
Quality LevelMQ100
Applications
ApplicationInSolution™ Cycloheximide, CAS 66-81-9, is a 100 mg/ml, sterile-filtered solution of Cycloheximide (Cat. No. 239763) in DMSO. An antifungal antibiotic that inhibits protein synthesis in eukaryotes.
Biological Information
Primary TargethFKBP12
Primary Target K<sub>i</sub>3.4 µM
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSMA4375000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Highly Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
239765 0

Documentation

InSolution™ Cycloheximide - CAS 66-81-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™ Cycloheximide - CAS 66-81-9 - Calbiochem Certificates of Analysis

TitleLot Number
239765

References

Reference overview
Christner, C., et al. 1999. J. Med. Chem. 42, 3615.
Lu, Q. and Mellgreen,R.L. 1996. Arch. Biochem. Biophys. 334, 175.
Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
Waring, P. 1990. J. Biol. Chem. 265, 14476.
Obrig, T.G., et al. 1971. J. Biol. Chem. 246, 174.
Pestka, S. 1971. Annu. Rev. Microbiol. 25, 487.

Citations

Title
  • Hui Zeng, et al. (2005) Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. American Journal of Physiology Gastrointestinal and Liver Physiology in press,.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision12-June-2008 RFH
    DescriptionA convenient ready-to-use form of Cycloheximide (Cat. No. 239763). An anti-fungal antibiotic that inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Also inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFKBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T-cell hybridomas, Burkitt's lymphoma cells, and a variety of other cell types, including rodent macrophages. Induces DNA fragmentation in macrophages, but inhibits DNA cleavage in rat thymocytes treated with thapsigargin, methylprednisolone, and ionomycin. Rapidly destroyed in alkaline solutions.
    FormLiquid
    FormulationA 100 mg/ml solution of Cycloheximide (Cat. No. 239763) in DMSO (sterile-filtered).
    Intert gas (Yes/No) Packaged under inert gas
    CAS number66-81-9
    RTECSMA4375000
    Chemical formulaC₁₅H₂₃NO₄
    Storage Protect from light
    +2°C to +8°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
    Toxicity Highly Toxic & Carcinogenic / Teratogenic
    ReferencesChristner, C., et al. 1999. J. Med. Chem. 42, 3615.
    Lu, Q. and Mellgreen,R.L. 1996. Arch. Biochem. Biophys. 334, 175.
    Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
    Waring, P. 1990. J. Biol. Chem. 265, 14476.
    Obrig, T.G., et al. 1971. J. Biol. Chem. 246, 174.
    Pestka, S. 1971. Annu. Rev. Microbiol. 25, 487.
    Citation
  • Hui Zeng, et al. (2005) Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. American Journal of Physiology Gastrointestinal and Liver Physiology in press,.
    		•