124039 Sigma-AldrichInSolution™ Akt Inhibitor X - CAS 925681-41-0 - Calbiochem
The InSolution™ Akt Inhibitor X, also referenced under CAS 925681-41-0, controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The InSolution™ Akt Inhibitor X, also referenced under CAS 925681-41-0, controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 10-DEBC HC, 10-(4ʹ-(N,N-Diethylamino)butyl)-2-chlorophenoxazine, HCl, 4-(2-Chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine, HCl
Recommended Products
Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 925681-41-0 | C₂₀H₂₅ClN₂O • HCl |
Products
| Catalogue Number | Packaging | Qty/Pack | |
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| 124039-2MG | Glass bottle | 2 mg |
| Description | |
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| Overview | A cell-permeable, reversible, and selective inhibitor of the phosphorylation of Akt and its in vitro kinase activity (complete inhibition < 5 µM) with minimal effect on PI 3-K, PDK1, or SGK1. Shown to suppress growth of Rh (rhabdomyosarcoma) cell lines (IC50 = 2-5 µM), inhibit IGF-I-stimulated nuclear translocation of Akt, and prevent phosphorylation of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein. Unlike Akti1/2 (Cat. No. 124018), the mode of inhibition is not PH domain-dependent. Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein. The solid form of this compound (Cat. No. 124020) is also available. |
| Catalogue Number | 124039 |
| Brand Family | Calbiochem® |
| Synonyms | 10-DEBC HC, 10-(4ʹ-(N,N-Diethylamino)butyl)-2-chlorophenoxazine, HCl, 4-(2-Chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine, HCl |
| References | |
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| References | Tsvetkov, A.S., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 16982. Thimmaiah, K.N., et al. 2005. J. Biol. Chem. 280, 31924. |
| Product Information | |
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| CAS number | 925681-41-0 |
| Form | Liquid |
| Formulation | A 20 mM (2 mg/262 µL) solution of Akt Inhibitor X (Cat. No. 124020) in H₂O. |
| Hill Formula | C₂₀H₂₅ClN₂O • HCl |
| Chemical formula | C₂₀H₂₅ClN₂O • HCl |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | Akt |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 124039-2MG | 04055977205855 |
Documentation
InSolution™ Akt Inhibitor X - CAS 925681-41-0 - Calbiochem SDS
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InSolution™ Akt Inhibitor X - CAS 925681-41-0 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 124039 |
References
| Reference overview |
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| Tsvetkov, A.S., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 16982. Thimmaiah, K.N., et al. 2005. J. Biol. Chem. 280, 31924. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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