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346110 Glucocorticoid Receptor Modulator, CpdA - CAS 14593-25-0 - Calbiochem

A cell-permeable aziridine precursor that acts as a nonsteroidal glucocorticoid receptor ligand with a binding affinity that is 4-fold higher than that of Dexamethasone.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-((4-Acetoxyphenyl)-2-chloro-N-methyl)ethylammonium chloride

Primary Target: A nonsteroidal glucocorticoid receptor (GR, Cat. No. 346100) ligand
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
14593-25-0C₁₁H₁₄ClNO₂ • HCl
Description
Overview

This product has been discontinued.



A cell-permeable aziridine precursor that acts as a nonsteroidal glucocorticoid receptor (GR, Cat. No. 346100) ligand with a binding affinity that is 4-fold higher than that of Dexamethasone (DEX, Cat. No. 265005). Induces GR nuclear translocation and selectively activates GR-mediated transrepression of the NF-κB-dependent production of pro-inflammatory cytokines. Unlike DEX, CpdA exhibits no effect on GRE- (glucocorticoid response element) driven gene expression. Reported to be as effective as DEX in suppressing acute inflammation in mice in vivo without the hyperglycemic side effect that is commonly associated with DEX.
Catalogue Number346110
Brand Family Calbiochem®
Synonyms2-((4-Acetoxyphenyl)-2-chloro-N-methyl)ethylammonium chloride
References
ReferencesDe Bosscher, K., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 15827.
Product Information
CAS number14593-25-0
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₁H₁₄ClNO₂ • HCl
Chemical formulaC₁₁H₁₄ClNO₂ • HCl
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetA nonsteroidal glucocorticoid receptor (GR, Cat. No. 346100) ligand
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Ethanol stock solutions are stable for up to 1 month at -70°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
346110 0

Documentation

Glucocorticoid Receptor Modulator, CpdA - CAS 14593-25-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Glucocorticoid Receptor Modulator, CpdA - CAS 14593-25-0 - Calbiochem Certificates of Analysis

TitleLot Number
346110

References

Reference overview
De Bosscher, K., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 15827.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-April-2011 RFH
Synonyms2-((4-Acetoxyphenyl)-2-chloro-N-methyl)ethylammonium chloride
DescriptionA cell-permeable aziridine precursor that acts as a nonsteroidal glucocorticoid receptor (GR, Cat. No. 346100) ligand with a binding affinity that is 4-fold higher than that of Dexamethasone (DEX, Cat. No. 265005). Induces GR nuclear translocation and selectively activates GR-mediated transrepression of the NF-κB-dependent production of pro-inflammatory cytokines. Unlike DEX, CpdA exhibits no effect on GRE- (glucocorticoid response element) driven gene expression. Reported to be as effective as DEX in suppressing acute inflammation in mice in vivo without the hyperglycemic side effect that is commonly associated with DEX.
FormWhite solid
CAS number14593-25-0
Chemical formulaC₁₁H₁₄ClNO₂ • HCl
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityEthanol (anhydrous, 5 mg/ml), DMSO (10 mg/ml), or H₂O (1 mg/ml)
Storage Protect from moisture
≤ -70°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Ethanol stock solutions are stable for up to 1 month at -70°C.
Toxicity Standard Handling
ReferencesDe Bosscher, K., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 15827.