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361564 GSK-3 Inhibitor XXIII, 3F8 - CAS 159109-11-2 - Calbiochem

The GSK-3 Inhibitor XXIII, 3F8, also referenced under CAS 159109-11-2, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-Ethyl-7,8-dimethoxy-1H-pyrrolo[3,4-c]-isoquinoline-1,3-(2H)-dione

361564
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
159109-11-2C₁₅H₁₄N₂O₄
Description
OverviewA cell-permeable maleimide compound that acts as a potent, reversible, and ATP-competitive inhibitor against GSK-3β (Cat. No. 361524) activity (IC50 = 34, 67 and 304 nM in the presence of 10, 30 and 100 µM ATP, respectively), while exhibiting much reduced activity against Cdk2/A, KDR (71% and 53% inhibition, respectively, at 5µM inhibitor concentration), and a panel of 19 other kinases (IC50 >5 µM). Shown to potently activate cellular Wnt pathway and increase β-catenin-dependent reporter transcription (by 15-fold at 4 µM) in 293T cultures in vitro and, when applied at or prior to the shield stage of embryo, interfere with zebrafish forebrain development in vivo.
Catalogue Number361564
Brand Family Calbiochem®
Synonyms5-Ethyl-7,8-dimethoxy-1H-pyrrolo[3,4-c]-isoquinoline-1,3-(2H)-dione
References
ReferencesZou, H., et al. 2010. J. Med. Chem. 53, 994.
Zhong, H., et al. 2009. Mol. BioSyst. 5, 1356.
Product Information
CAS number159109-11-2
FormYellow solid
Hill FormulaC₁₅H₁₄N₂O₄
Chemical formulaC₁₅H₁₄N₂O₄
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
361564 0

Documentation

GSK-3 Inhibitor XXIII, 3F8 - CAS 159109-11-2 - Calbiochem Certificates of Analysis

TitleLot Number
361564

References

Reference overview
Zou, H., et al. 2010. J. Med. Chem. 53, 994.
Zhong, H., et al. 2009. Mol. BioSyst. 5, 1356.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-April-2011 RFH
Synonyms5-Ethyl-7,8-dimethoxy-1H-pyrrolo[3,4-c]-isoquinoline-1,3-(2H)-dione
DescriptionA cell-permeable maleimide compound that acts as a potent, reversible, and ATP-competitive inhibitor against GSK-3β (Cat. No. 361524) activity (IC50 = 34, 67 and 304 nM in the presence of 10, 30 and 100 µM ATP, respectively), while exhibiting much reduced activity against Cdk2/A, KDR (71% and 53% inhibition, respectively, at 5µM inhibitor concentration), and a panel of 19 other kinases (IC50 >5 µM). Shown to potently activate cellular Wnt pathway and increase β-catenin-dependent reporter transcription (by 15-fold at 4 µM) in 293T cultures in vitro and, when applied at or prior to the shield stage of embryo, interfere with zebrafish forebrain development in vivo.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number159109-11-2
Chemical formulaC₁₅H₁₄N₂O₄
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesZou, H., et al. 2010. J. Med. Chem. 53, 994.
Zhong, H., et al. 2009. Mol. BioSyst. 5, 1356.