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361541 GSK-3β Inhibitor II - CAS 478482-75-6 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Glycogen Synthase Kinase-3β Inhibitor II, 2-Thio(3-iodobenzyl)-5-(1-pyridyl)-[1,3,4]-oxadiazole

Primary Target: Gsk-3β
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
478482-75-6C₁₄H₁₀IN₃OS
Description
Overview

This product has been discontinued.



A 2-thio-[1,3,4]-oxadiazole-pyridyl derivative that acts as a potent inhibitor of glycogen synthase kinase-3β (IC50 = 390 nM).
Catalogue Number361541
Brand Family Calbiochem®
SynonymsGlycogen Synthase Kinase-3β Inhibitor II, 2-Thio(3-iodobenzyl)-5-(1-pyridyl)-[1,3,4]-oxadiazole
References
ReferencesNaerum, L., et al. 2002. Bioorg. Med. Chem. Lett. 12, 1525.
Product Information
CAS number478482-75-6
ATP CompetitiveN
FormYellow solid
Hill FormulaC₁₄H₁₀IN₃OS
Chemical formulaC₁₄H₁₀IN₃OS
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetGsk-3β
Primary Target IC<sub>50</sub>390 nM against glycogen synthase kinase-3β
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
361541 0

Documentation

GSK-3β Inhibitor II - CAS 478482-75-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

GSK-3β Inhibitor II - CAS 478482-75-6 - Calbiochem Certificates of Analysis

TitleLot Number
361541

References

Reference overview
Naerum, L., et al. 2002. Bioorg. Med. Chem. Lett. 12, 1525.

Brochure

Title
Alzheimer's Disease Brochure & Technical Guide
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-october-2007 JSW
SynonymsGlycogen Synthase Kinase-3β Inhibitor II, 2-Thio(3-iodobenzyl)-5-(1-pyridyl)-[1,3,4]-oxadiazole
DescriptionA 2-thio-[1,3,4]-oxadiazole-pyridyl derivative that acts as a potent inhibitor of glycogen synthase kinase-3b (IC50 = 390 nM).

FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number478482-75-6
Chemical formulaC₁₄H₁₀IN₃OS
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesNaerum, L., et al. 2002. Bioorg. Med. Chem. Lett. 12, 1525.