Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

364205 GM 6001 - CAS 142880-36-2 - Calbiochem

GM 6001, CAS 142880-36-2, is a potent, cell-permeable, broad-spectrum inhibitor of MMPs (Ki = 400 pM for MMP-1; 500 pM for MMP-2; 27 nM for MMP-3; 100 pM for MMP-8; and 200 pM for MMP-9).

GM 6001 - CAS 142880-36-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Galardin, N-[(2R)-2-(Hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan Methylamide

Primary Target: MMP-1
View Products on Sigmaaldrich.com
364205
Purchase on Sigma-Aldrich

Overview

Key Spec Table

CAS #Empirical Formula
142880-36-2C₂₀H₂₈N₄O₄

Products

Catalogue NumberPackaging Qty/Pack
364205-1MG Plastic ampoule 1 mg
Add To Favorites
364205-5MG Plastic ampoule 5 mg
Add To Favorites
Description
OverviewA potent, cell-permeable, broad-spectrum hydroxamic acid inhibitor of matrix metalloproteinases (MMPs); (Ki = 400 pM for MMP-1; Ki = 500 pM for MMP-2; Ki = 27 nM for MMP-3; Ki = 100 pM for MMP-8; and Ki = 200 pM for MMP-9). Prevents the release of TNF-α in vivo and in vitro and abrogates endotoxin-induced lethality in mice. A 10 mM (1 mg/257 µl) solution of GM6001 (Cat. No. 364206) in DMSO is also available.
Catalogue Number364205
Brand Family Calbiochem®
SynonymsGalardin, N-[(2R)-2-(Hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan Methylamide
References
ReferencesSolorzano, C.C., et al. 1997. Shock 7, 427.
Galardy, R.E., et al. 1994. Ann. NY Acad. Sci. 732, 315.
Galardy, R.E., et al. 1994. Cancer Res. 54, 4715.
Galardy, R.E. 1993. Drugs Future 18, 1109.
Grobelny, D., et al. 1992. Biochemistry 31, 7152.
Product Information
CAS number142880-36-2
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₂₀H₂₈N₄O₄
Chemical formulaC₂₀H₂₈N₄O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationGM 6001, CAS 142880-36-2, is a potent, cell-permeable, broad-spectrum inhibitor of MMPs (Ki = 400 pM for MMP-1; 500 pM for MMP-2; 27 nM for MMP-3; 100 pM for MMP-8; and 200 pM for MMP-9).
Biological Information
Primary TargetMMP-1
Primary Target K<sub>i</sub>400 pM for MMP-1; 500 pM for MMP-2; 27 nM for MMP-3; 100 pM for MMP-8; 200 pM for MMP-9
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Global Trade Item Number
Catalogue Number GTIN
364205-1MG 04055977213744
364205-5MG 04055977213799