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344847 Fumitremorgin C, Aspergillus. fumigatus - CAS 118974-02-0 - Calbiochem

Fumitremorgin C, Aspergillus. Fumigatus, CAS 118974-02-0, is a cell-permeable chemo-sensitizing agent that inhibits BCRP/ABCG2 multidrug transport activity.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: NSC719655, FTC

Primary Target: BCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2)
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
118974-02-0C₂₂H₂₅N₃O₃

Products

Catalogue NumberPackaging Qty/Pack
344847-250UG Plastic ampoule 250 μg
Description
OverviewA cell-permeable indolyldiketopiperazinyl mycotoxin that inhibits BCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2) multidrug transport activity. Also acts as a potent and specific chemosenzitizing agent.
Catalogue Number344847
Brand Family Calbiochem®
SynonymsNSC719655, FTC
References
ReferencesAllen, J.D., et al. 2002. Mol. Cancer Ther. 1, 417.
Ozvegy, C., et al. 2001. Biochem. Biophys. Res. Commun. 285, 111.
Rabindran, S.K., et al. 2000. Cancer Res. 60, 47.
Rabindran, S.K., et al. 1998. Cancer Res. 58, 5850.
Cole, R.J., et al. 1977. J. Agric. Food Chem. 25, 826.
Product Information
CAS number118974-02-0
ATP CompetitiveN
FormLyophilized
Hill FormulaC₂₂H₂₅N₃O₃
Chemical formulaC₂₂H₂₅N₃O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationFumitremorgin C, Aspergillus. Fumigatus, CAS 118974-02-0, is a cell-permeable chemo-sensitizing agent that inhibits BCRP/ABCG2 multidrug transport activity.
Biological Information
Primary TargetBCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2)
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
344847-250UG 04055977214864

Documentation

Fumitremorgin C, Aspergillus. fumigatus - CAS 118974-02-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Fumitremorgin C, Aspergillus. fumigatus - CAS 118974-02-0 - Calbiochem Certificates of Analysis

TitleLot Number
344847

References

Reference overview
Allen, J.D., et al. 2002. Mol. Cancer Ther. 1, 417.
Ozvegy, C., et al. 2001. Biochem. Biophys. Res. Commun. 285, 111.
Rabindran, S.K., et al. 2000. Cancer Res. 60, 47.
Rabindran, S.K., et al. 1998. Cancer Res. 58, 5850.
Cole, R.J., et al. 1977. J. Agric. Food Chem. 25, 826.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-May-2008 RFH
SynonymsNSC719655, FTC
DescriptionA cell-permeable indolyldiketopiperazinyl mycotoxin that inhibits the ATPase and multidrug resistance activity of BCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2) without affecting the activity of MDR1. Also acts as a potent and specific chemosenzitizing agent. Suggested concentration for cell inhibition studies: ~1-5 µM.
FormLyophilized
Intert gas (Yes/No) Packaged under inert gas
CAS number118974-02-0
Chemical formulaC₂₂H₂₅N₃O₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Toxic
ReferencesAllen, J.D., et al. 2002. Mol. Cancer Ther. 1, 417.
Ozvegy, C., et al. 2001. Biochem. Biophys. Res. Commun. 285, 111.
Rabindran, S.K., et al. 2000. Cancer Res. 60, 47.
Rabindran, S.K., et al. 1998. Cancer Res. 58, 5850.
Cole, R.J., et al. 1977. J. Agric. Food Chem. 25, 826.