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341609 FGF Receptor Tyrosine Kinase Inhibitor IV, NP603 - CAS 949164-80-1 - Calbiochem

The FGF Receptor Tyrosine Kinase Inhibitor IV, NP603 controls the biological activity of FGF Receptor Tyrosine KInase. Primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (Z)-3-(5-(6-(3,5-Dimethoxyphenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrol-3-yl)-propionic acid, NP603, VEGFR Tyrosine Kinase Inhibitor XXIX, VEGFR2 Kinase Inhibitor XXVII, PDGFR Tyrosine Kinase Inhibitor XVI

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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
949164-80-1C₂₆H₂₆N₂O₅
Description
OverviewA cell-permeable SU6668 (PDGFR Tyrosine Kinase Inhibitor VI, Cat. No. 521235) derivative that targets the ATP-binding pocket and inhibits the kinase activity of FGFR1, PDGFRβ, and VEGFR2 (IC50 = 520, 780, and 930 nM, respectively), while exhibiting little activity against EGFR (IC50 >100 µM). Shown to exhibit anti-angiogenesis activity and suppress FGF-2-induced proliferation (IC50 = 18.2 µM) in HUVEC cultures in a dose-dependent manner.
Catalogue Number341609
Brand Family Calbiochem®
Synonyms(Z)-3-(5-(6-(3,5-Dimethoxyphenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrol-3-yl)-propionic acid, NP603, VEGFR Tyrosine Kinase Inhibitor XXIX, VEGFR2 Kinase Inhibitor XXVII, PDGFR Tyrosine Kinase Inhibitor XVI
References
ReferencesKammasud, N., et al. 2009. Bioorg. Med. Chem. Lett. 19, 745.
Kammasud, N., et al. 2007. Bioorg. Med. Chem. Lett. 17, 4812.
Product Information
CAS number949164-80-1
FormOrange solid
Hill FormulaC₂₆H₂₆N₂O₅
Chemical formulaC₂₆H₂₆N₂O₅
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 22-36/37/38

Harmful if swallowed.
Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
341609 0

Documentation

FGF Receptor Tyrosine Kinase Inhibitor IV, NP603 - CAS 949164-80-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

FGF Receptor Tyrosine Kinase Inhibitor IV, NP603 - CAS 949164-80-1 - Calbiochem Certificates of Analysis

TitleLot Number
341609

References

Reference overview
Kammasud, N., et al. 2009. Bioorg. Med. Chem. Lett. 19, 745.
Kammasud, N., et al. 2007. Bioorg. Med. Chem. Lett. 17, 4812.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-May-2011 RFH
Synonyms(Z)-3-(5-(6-(3,5-Dimethoxyphenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrol-3-yl)-propionic acid, NP603, VEGFR Tyrosine Kinase Inhibitor XXIX, VEGFR2 Kinase Inhibitor XXVII, PDGFR Tyrosine Kinase Inhibitor XVI
DescriptionA cell-permeable SU6668 (PDGFR Tyrosine Kinase Inhibitor VI, Cat. No. 521235) derivative that targets the ATP-binding pocket and inhibits the kinase activity of FGFR1, PDGFRβ, and VEGFR2 (IC50 = 520, 780, and 930 nM, respectively), while exhibiting little activity against EGFR (IC50 >100 µM). Shown to exhibit anti-angiogenesis activity and suppress FGF-2-induced proliferation (IC50 = 18.2 µM) in HUVEC cultures in a dose-dependent manner.
FormOrange solid
Intert gas (Yes/No) Packaged under inert gas
CAS number949164-80-1
Chemical formulaC₂₆H₂₆N₂O₅
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
ReferencesKammasud, N., et al. 2009. Bioorg. Med. Chem. Lett. 19, 745.
Kammasud, N., et al. 2007. Bioorg. Med. Chem. Lett. 17, 4812.